Dexamethasone and Etoricoxib for Pain Prevention Following Periodontal Surgery
Phase 2
Completed
- Conditions
- Pain Control
- Registration Number
- NCT00970112
- Lead Sponsor
- Universidade Estadual de Ponta Grossa
- Brief Summary
The purpose of this study is to investigate whether preemptive medication with dexamethasone or etoricoxib provides better pain management and control than placebo following periodontal surgery.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
- Patients presenting moderate or severe periodontitis after nonsurgical periodontal treatment with clinical signs of inflammation
Exclusion Criteria
- Pregnant
- Diabetes mellitus
- Heart diseases
- Allergic to components of the medications
- Risk of endocarditis
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method pain up to 3 days hourly for the 8 first hours after surgery 3 times a day on the following 3 days
- Secondary Outcome Measures
Name Time Method
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie dexamethasone's preemptive analgesic effect compared to COX-2 inhibition by etoricoxib in periodontal surgery?
How does preemptive dexamethasone or etoricoxib compare to standard-of-care NSAIDs for postoperative pain control in periodontal procedures?
Are there inflammatory biomarkers predictive of response to dexamethasone or etoricoxib in postoperative pain management following periodontal surgery?
What are the potential adverse events associated with preemptive corticosteroid (dexamethasone) use in periodontal surgery, and how do they compare to COX-2 inhibitor (etoricoxib) risks?
What combination therapies involving glucocorticoids and selective COX-2 inhibitors are being evaluated for enhanced postoperative pain prevention in dental surgery?
Trial Locations
- Locations (1)
UEPG
🇧🇷Ponta Grossa, Paraná, Brazil
UEPG🇧🇷Ponta Grossa, Paraná, Brazil