Effect of Suicidality on Social Cognition
- Conditions
- Major Depressive DisorderSuicide
- Interventions
- Behavioral: Clinical InterviewBehavioral: Clinical QuestionnairesOther: Brain ScanBehavioral: Behavioural Games
- Registration Number
- NCT06163612
- Lead Sponsor
- Unity Health Toronto
- Brief Summary
Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. The prevalence of suicide attempt in Major Depressive Disorder (MDD) is about 20%. Risk for suicide attempt can be increased by many things such as negative life events, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors.
In this study, the investigators will be collecting detailed information about participants' psychiatric history and depression symptoms, as well as brain scans. The goal is to use this information to help us determine what predicts suicide attempt history.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- RECRUITING
- Sex
- All
- Target Recruitment
- 150
Not provided
Not provided
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Healthy controls, or people who do not have depression. Clinical Interview - Healthy controls, or people who do not have depression. Behavioural Games - People diagnosed with MDD and a history of suicide attempt Brain Scan - People diagnosed with MDD and a history of suicide attempt Behavioural Games - Healthy controls, or people who do not have depression. Brain Scan - Healthy controls, or people who do not have depression. Clinical Questionnaires - People diagnosed with MDD and a history of suicide attempt Clinical Interview - People diagnosed with MDD and a history of suicide attempt Clinical Questionnaires - People diagnosed with MDD without a history of suicide attempt Clinical Interview - People diagnosed with MDD without a history of suicide attempt Clinical Questionnaires - People diagnosed with MDD without a history of suicide attempt Behavioural Games - People diagnosed with MDD without a history of suicide attempt Brain Scan -
- Primary Outcome Measures
Name Time Method fMRI Markers for Suicide Risk Through study completion, an average of 1 week Potential fMRI brain activity for suicide risk using participants' brain scans
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Unity Health Toronto
🇨🇦Toronto, Ontario, Canada