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Effect of Suicidality on Social Cognition

Recruiting
Conditions
Major Depressive Disorder
Suicide
Interventions
Behavioral: Clinical Interview
Behavioral: Clinical Questionnaires
Other: Brain Scan
Behavioral: Behavioural Games
Registration Number
NCT06163612
Lead Sponsor
Unity Health Toronto
Brief Summary

Major Depressive Disorder (MDD) is a very common illness that is usually treated with antidepressant medication. Depression can be caused by many things such as childhood experiences, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors. The prevalence of suicide attempt in Major Depressive Disorder (MDD) is about 20%. Risk for suicide attempt can be increased by many things such as negative life events, genetics, and changes in the way the body and brain function. It is most likely caused by a combination of several of these factors.

In this study, the investigators will be collecting detailed information about participants' psychiatric history and depression symptoms, as well as brain scans. The goal is to use this information to help us determine what predicts suicide attempt history.

Detailed Description

Not available

Recruitment & Eligibility

Status
RECRUITING
Sex
All
Target Recruitment
150
Inclusion Criteria

Not provided

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Exclusion Criteria

Not provided

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Study & Design

Study Type
OBSERVATIONAL
Study Design
Not specified
Arm && Interventions
GroupInterventionDescription
Healthy controls, or people who do not have depression.Clinical Interview-
Healthy controls, or people who do not have depression.Behavioural Games-
People diagnosed with MDD and a history of suicide attemptBrain Scan-
People diagnosed with MDD and a history of suicide attemptBehavioural Games-
Healthy controls, or people who do not have depression.Brain Scan-
Healthy controls, or people who do not have depression.Clinical Questionnaires-
People diagnosed with MDD and a history of suicide attemptClinical Interview-
People diagnosed with MDD and a history of suicide attemptClinical Questionnaires-
People diagnosed with MDD without a history of suicide attemptClinical Interview-
People diagnosed with MDD without a history of suicide attemptClinical Questionnaires-
People diagnosed with MDD without a history of suicide attemptBehavioural Games-
People diagnosed with MDD without a history of suicide attemptBrain Scan-
Primary Outcome Measures
NameTimeMethod
fMRI Markers for Suicide RiskThrough study completion, an average of 1 week

Potential fMRI brain activity for suicide risk using participants' brain scans

Secondary Outcome Measures
NameTimeMethod

Trial Locations

Locations (1)

Unity Health Toronto

🇨🇦

Toronto, Ontario, Canada

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