Functional vascular analyzis for prediction of pre-eclampsia

Recruiting

• Conditions: O14; O36.5; Pre-eclampsia; Maternal care for poor fetal growth

• Registration Number: DRKS00024904
• Lead Sponsor: niversitätsfrauenklinik und Poliklinik am Klinikum Südstadt Rostock

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2021-04-20
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Female
• Target Recruitment: 170

Inclusion Criteria

pregravid obesity (body mass index equal or greater 30 kg/squaremeters befor pregnancy) and/or mean pulsatility index (PI) of the uterine arteries greater than 95. centile

Exclusion Criteria

person not capable of giving consent, no informed consent, intrauterine fetal death, chromosomal aberrations, severe fetal malformations, premature preterm rupture of membranes, known anti-phospholipid syndrome, history of pre-eclampsia or pregnancy induced hypertension in a previous pregnancy, multiple gestation, chronic kidney disease, diabetes mellitus type 1, eye diseased of diagnostic relevance: cloudiness of the optical media, missing adherence, relevant diseases of the cornea and retina, existence of at least one of the following lab criterions at time point of study inclusion: creatinine = 90µmol/l, proteinuria = 300mg/d, protein creatinine ratio = 0,3 mg/mg or u-stick > 1+, ALT/AST > 40 IU/l resp. >0,67µkat/l, platelets < 150 x 10^9/l.

Study & Design

• Study Type: observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Development of pre-eclampsia (in accordance to ISSHP criterions)

Secondary Outcome Measures

Name	Time	Method
Development of pregnancy induced arterial hypertension (in accordance to ISSHP criterions) or intrauterine growth restriction in accordance to the German guideline.