Impact of nCPAP Treatment on Liver Function in Patients With Sleep Apnea Syndrome and Nonalcoholic Steatohepatitis

Not Applicable

• Conditions: Sleep Apnea Syndrome; Nonalcoholic Steatohepatitis

• Registration Number: NCT00152711
• Lead Sponsor: University Hospital, Angers

Brief Summary

This study aims to evaluate the impact of nasal continuous positive airway pressure (nCPAP) treatment on liver enzymes in patients with sleep apnea syndrome and nonalcoholic steatohepatitis. Using a cross over design, the evolution of liver enzymes will be evaluated in 40 patients during a consecutive period of 6 weeks, with and without nCPAP treatment.

Detailed Description

Not available

Study Timeline

• Study Start: 2004-09
• Status Verified: 2005-09
• Study First Submitted: 2005-09-08
• Study First Submitted QC: 2005-09-08
• Study First Posted: 2005-09-09
• Last Update Submitted: 2007-02-12
• Last Update Posted: 2007-02-13

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

• 18 to 70 years old
• Nonalcoholic steatohepatitis proven by liver biopsy
• Sleep apnea syndrome proven by polysomnography with an apnea-hypopnea index > 10 events/hour
• Informed consent

Exclusion Criteria

• Psychiatric disorder
• Other cause of liver disease
• Professional driver

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: CROSSOVER

Trial Locations

Locations (1)

University Hospital Angers; 🇫🇷 Angers, France