MedPath

Clostridium Difficile Vaccine Efficacy Trial

Phase 3
Completed
Conditions
Clostridium Difficile Infection
Interventions
Biological: Clostridium difficile vaccine
Biological: Placebo
Registration Number
NCT03090191
Lead Sponsor
Pfizer
Brief Summary

The Clover trial is evaluating an investigational vaccine that may help to prevent Clostridium difficile infection. Participants in the study are adults 50 years of age and older, who are at risk of developing Clostridium difficile infection. The study will assess whether the vaccine prevents the disease, and whether it is safe and well tolerated.

Each subject will receive 3 doses of Clostridium difficile vaccine or placebo and be followed for up to 3 years after vaccination for potential Clostridium difficile infection.

Detailed Description

Not available

Recruitment & Eligibility

Status
COMPLETED
Sex
All
Target Recruitment
17535
Inclusion Criteria
  • Evidence of a personally signed and dated informed consent document.
  • Willing and able to comply with study procedures.
  • Subjects with an increased risk of future contact with healthcare systems or subjects who have received systemic antibiotics in the previous 12 weeks.
  • Ability to be contacted by telephone during study participation.
  • Negative urine pregnancy test for female subjects of childbearing potential.
Exclusion Criteria
  • Investigator site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or subjects who are Pfizer employees, including their family members, directly involved in the conduct of the study.

  • Participation in other studies involving investigational drug(s)/vaccine(s) within 28 days prior to study entry until 1 month after the third vaccination.

  • Previous administration of an investigational C difficile vaccine or C difficile mAb therapy.

  • Prior episode of CDI..

  • Receipt of blood products or immunoglobulins within 6 months before enrollment.

  • Subjects who may be unable to respond to vaccination due to:

    • Metastatic malignancy; or
    • End-stage renal disease; or
    • Any serious medical disorder likely to be fatal within the next 12 months; or
    • Congenital or acquired immunodeficiency; or
    • Receipt of high dose systemic corticosteroids for 14 days within 28 days of enrollment; or
    • Receipt of chronic systemic treatment with other known immunosuppressant medications, or radiotherapy, within 6 months of enrollment.
  • Known infection with human immunodeficiency virus (HIV).

  • Any bleeding disorder or anticoagulant therapy that would contraindicate intramuscular injection.

  • Any contraindication to vaccination or vaccine components, including previous anaphylactic reaction to any vaccine or vaccine-related components.

  • Prior small- or large-bowel resection.

  • Any condition or treatment resulting in frequent diarrhea.

  • Other acute or chronic condition or abnormality that may increase the risk associated with study participation or IP administration or may interfere with interpretation of study results

  • Pregnant or breastfeeding female subjects; male subjects and female subjects who are sexually active and at risk for pregnancy and will not/cannot use 2 methods of contraception

Study & Design

Study Type
INTERVENTIONAL
Study Design
PARALLEL
Arm && Interventions
GroupInterventionDescription
Clostridium difficile vaccineClostridium difficile vaccine-
PlaceboPlacebo-
Primary Outcome Measures
NameTimeMethod
Number of First Primary Episodes of Clostridium Difficile Infection (CDI) (Definition 1) Follow-up After Dose 3From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by polymerase chain reaction \[PCR)\] and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of First Primary Episodes of Clostridium Difficile Infection (CDI) (Definition 1) Follow-up After Dose 2From 14 days after Dose 2 to the end of the surveillance period (mean follow-up after dose 2 was 36 months)

CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 1Within 7 days after Dose 1 at Month 0

Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an electronic diary (e-diary). Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 centimeter (cm) and graded as mild: 2.5 to 5.0 cm, moderate: greater than (\>) 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 2Within 7 days after Dose 2 at Month 1

Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an e-diary. Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 cm and graded as mild: 2.5 to 5.0 cm, moderate: \> 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling. Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

Percentage of Participants Reporting Local Reactions Within 7 Days After Dose 3Within 7 days after Dose 3 at Month 6

Local reactions included redness, swelling and pain at injection site. These were recorded by participants in an e-diary. Redness and swelling were measured and recorded in measuring device units. One measuring device unit= 0.5 cm and graded as mild: 2.5 to 5.0 cm, moderate: \> 5.0 to 10.0 cm, severe: \>10.0 cm. Grade 4 indicated necrosis or exfoliative dermatitis for redness and necrosis for swelling. Pain at injection site was graded as mild: did not interfere with daily activity, moderate: interfered with daily activity, severe: prevented daily activity. Grade 4 indicated emergency room visit or hospitalization.

Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 1Within 7 days after Dose 1 at Month 0

Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 degree Celsius \[deg C\]), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 2Within 7 days after Dose 2 at Month 1

Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 deg C), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

Percentage of Participants Reporting Systemic Events Within 7 Days After Dose 3Within 7 days after Dose 3 at Month 6

Systemic events included fever, fatigue, headache, joint pain, muscle pain and vomiting. These were recorded by participants in an e-diary. Fever was categorized as: mild: (38.0 to 38.4 deg C), moderate: (38.5 to 38.9 deg C), severe (39.0 to 40.0 deg C), potentially life threatening (\> 40.0 deg C). Fatigue, headache, joint pain and muscle pain were graded as mild: did not interfere with activity, moderate: some interference with activity, severe: prevented daily activity, grade 4: emergency room visit or hospitalization. Vomiting was graded as mild: 1 to 2 times in 24 hours, moderate: \>2 times in 24 hours, severe: required intravenous hydration, grade 4: emergency room visit or hospitalization for hypotensive shock.

Number of Participants Reporting Adverse Events (AEs)From Day 1 of Dose 1 to 1 Month after Dose 3 (7 Months)

An AE was defined as any untoward medical occurrence in a participant who received investigational product without regard to possibility of causal relationship. AEs included both serious and all non-serious adverse events. An SAE was defined as any untoward medical occurrence at any dose that resulted in any of the following outcomes: death; life-threatening (immediate risk of death); required inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity (substantial disruption of the ability to conduct normal life functions); congenital anomaly/birth defect; or that was considered as an important medical event. AEs included both SAEs and all Non-SAEs (except local and systemic events).

Number of Participants Reporting Serious Adverse Events (SAEs)From Day 1 of Dose 1 up to 6 months after Dose 3 (up to Month 12)

An SAE was defined as any untoward medical occurrence at any dose that resulted in any of the following outcomes: death; life-threatening (immediate risk of death); required inpatient hospitalization or prolongation of existing hospitalization; persistent or significant disability/incapacity (substantial disruption of the ability to conduct normal life functions); congenital anomaly/birth defect; or that was considered as an important medical event.

Secondary Outcome Measures
NameTimeMethod
Number of All Episodes of CDI (Definition 1 and 2) After Dose 3From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

CDI definition 1 for primary episode of CDI (no previous CDI onset in prior 8 weeks) and CDI definition 2 for recurrent episode (episode occurred 8 weeks or less after onset of previous episode \[provided symptoms of previous episode resolved\]) were both defined as either a) presence of diarrhea, (passage of 3 or more unformed stools \[Bristol stool chart types 5-7\]) in 24 or fewer consecutive hours, stool sample positive for toxin B gene (by PCR),positive for toxin A and/or toxin B, as measured in central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, surgery, histopathologically; and corresponding stool sample positive for toxin B gene (via PCR) as measured in central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Time to Resolution for Participants With First Primary Episodes of CDI (Definition 1) After Dose 3From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

Resolution of the event was the last day on which the event was recorded in the e-diary or the date the event ends if it was unresolved during the participant diary-recording period (end date collected on the case report form \[CRF\]). CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Proportion of Participants Who Required Medical Attention During First Primary Episode of CDI (Definition 1) After Dose 3From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of Participants With Recurrent Episodes of CDI (Definition 2) After Dose 3From 14 days after Dose 3 to the end of the surveillance period (mean follow-up after dose 3 was 34.2 months)

CDI definition 2 for a recurrent episode (an episode of CDI that occurred 8 weeks or less after the onset of a previous CDI episode \[provided the symptoms of the previous episode had resolved\]), was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours; and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (by PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of All Episodes of CDI (Definition 1 and 2) After Dose 2From 14 days after Dose 2 to the end of the surveillance period (mean follow-up after dose 2 was 36 months)

CDI definition 1 for primary episode of CDI (no previous CDI onset in prior 8 weeks) and CDI definition 2 for recurrent episode (episode occurred 8 weeks or less after onset of previous episode \[provided symptoms of previous episode resolved\]) were both defined as either a) presence of diarrhea, (passage of 3 or more unformed stools \[Bristol stool chart types 5-7\]) in 24 or fewer consecutive hours, stool sample positive for toxin B gene (by PCR),positive for toxin A and/or toxin B, as measured in central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, surgery, histopathologically; and corresponding stool sample positive for toxin B gene (via PCR) as measured in central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of Participants With Recurrent Episodes of CDI (Definition 2) After Dose 2From 14 days after Dose 2 to the end of the surveillance period (mean follow-up after dose 2 was 36 months)

CDI definition 2 for a recurrent episode (an episode of CDI that occurred 8 weeks or less after the onset of a previous CDI episode \[provided the symptoms of the previous episode had resolved\]), was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours; and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (by PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of First Primary Episode of CDI (Definition 1) After Dose 2 and Before Dose 3From 14 days after Dose 2 to Dose 3 or the day the third vaccination was expected (168 days after Dose 2) for participants who received only 2 doses

CDI definition 1 for a primary episode of CDI (no previous CDI onset in the prior 8 weeks) was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours, and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (via PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Number of Participants With Recurrent Episode of CDI (Definition 2) After Dose 2 and Before Dose 3From 14 days after Dose 2 to Dose 3 or the day the third vaccination was expected (168 days after Dose 2) for participants who received only 2 doses

CDI definition 2 for a recurrent episode (an episode of CDI that occurred 8 weeks or less after the onset of a previous CDI episode \[provided the symptoms of the previous episode had resolved\]), was defined as either a) presence of diarrhea, defined as passage of 3 or more unformed stools (Bristol stool chart types 5-7) in 24 or fewer consecutive hours; and stool sample that was positive for the toxin B gene (by PCR) and positive for toxin A and/or toxin B, as measured in the central laboratory; or b) Pseudomembranous colitis diagnosed at colonoscopy, at surgery, or histopathologically; and corresponding stool sample that was positive for the toxin B gene (by PCR) as measured in the central laboratory. End of surveillance period was defined as accumulation of at least 40 CDI cases.

Trial Locations

Locations (418)

Clinical Research Consulting, LLC

🇺🇸

Milford, Connecticut, United States

Bay Pines VA Healthcare System

🇺🇸

Bay Pines, Florida, United States

Multi-Specialty Research Associates, Inc.

🇺🇸

Lake City, Florida, United States

Soma Medical Center

🇺🇸

West Palm Beach, Florida, United States

Charisma Medical and Research Center

🇺🇸

Miami Lakes, Florida, United States

Fleming Island Center for Clinical Research

🇺🇸

Fleming Island, Florida, United States

Ocean Blue Medical Research Center, Inc.

🇺🇸

Miami Springs, Florida, United States

Pines Care Research Center, LLC

🇺🇸

Pembroke Pines, Florida, United States

Progressive Medical Research

🇺🇸

Port Orange, Florida, United States

Precision Clinical Research, LLC

🇺🇸

Sunrise, Florida, United States

Luminis Health Anne Arundel Medical Center

🇺🇸

Annapolis, Maryland, United States

Luminis Health Research Institute: Research Office

🇺🇸

Annapolis, Maryland, United States

ClinSite, LLC

🇺🇸

Canton, Michigan, United States

Bozeman Health Deaconess Hospital d/b/a Bozeman Health Clinical Research

🇺🇸

Bozeman, Montana, United States

Mercury Street Medical Group, PLLC

🇺🇸

Butte, Montana, United States

ID Care

🇺🇸

Hillsborough, New Jersey, United States

Amici Clinical Research

🇺🇸

Raritan, New Jersey, United States

South Jersey Infectious Disease

🇺🇸

Somers Point, New Jersey, United States

J. Lewis Research Inc. / Foothill Family Clinic Draper

🇺🇸

Draper, Utah, United States

PMG Research,Inc. d/b/a PMG Research of Knoxville

🇺🇸

Knoxville, Tennessee, United States

Holston Medical Group

🇺🇸

Bristol, Tennessee, United States

Internal Medicine and Pediatric Associates of Bristol, PC

🇺🇸

Bristol, Tennessee, United States

PMG Research of Bristol, LLC

🇺🇸

Bristol, Tennessee, United States

The Ottawa Hospital Civic Campus

🇨🇦

Ottawa, Ontario, Canada

Clinical Neuroscience Solutions, Inc.

🇺🇸

Memphis, Tennessee, United States

Trinity Clinical Research

🇺🇸

Tullahoma, Tennessee, United States

MC ''Tsaritsa Yoanna''EOOD

🇧🇬

Sliven, Bulgaria

Hospital Italiano de Buenos Aires

🇦🇷

C.a.b.a., Buenos Aires, Argentina

J. Lewis Research, Inc. - Jordan River Family Medicine

🇺🇸

South Jordan, Utah, United States

Marshfield Medical Center - Marshfield

🇺🇸

Marshfield, Wisconsin, United States

"Acibadem City Clinic University Hospital" EOOD

🇧🇬

Sofia, Bulgaria

MHAT "Sveta Anna - Sofia" AD, Clinic of Internal Diseases

🇧🇬

Sofia, Bulgaria

Fundacion Cardiovascular de Colombia

🇨🇴

Floridablanca, Santander, Colombia

Studienzentrum Nordwest

🇩🇪

Westerstede, Germany

Centro Medico Imbanaco de Cali S.A.

🇨🇴

Cali, Valle DEL Cauca, Colombia

Universitaetsmedizin Rostock

🇩🇪

Rostock, Germany

Praxis Dr. med. J. Springub/ W. Schwarz

🇩🇪

Westerstede, Germany

Iizuka Hospital

🇯🇵

Iizuka, Fukuoka, Japan

Semmelweis Egyetem III. Sz. Belgyogyaszati Klinika

🇭🇺

Budapest, Hungary

Orszagos Koranyi Pulmonologiai Intezet, VI. Osztaly

🇭🇺

Budapest, Hungary

DRC Kft.

🇭🇺

Balatonfured, Hungary

Del-pesti Centrumkorhaz - Orszagos Hematologiai es Infektologiai Intezet, I. Belgyogyaszati Osztaly

🇭🇺

Budapest, Hungary

CRU Hungary Kft.

🇭🇺

Encs, Hungary

Aichi Medical University Hospital

🇯🇵

Nagakute, Aichi, Japan

Miyanomori Memorial Hospital

🇯🇵

Sapporo-shi, Hokkaido, Japan

Nerima General Hospital

🇯🇵

Nerima-ku, Tokyo, Japan

Seishinkai Inoue Hospital

🇯🇵

Itoshima, Fukuoka, Japan

Fukuoka Tokushukai Hospital

🇯🇵

Kasuga, Fukuoka, Japan

Kenwakai Otemachi Hospital

🇯🇵

Kitakyushu, Fukuoka, Japan

Fukuyama City Hospital

🇯🇵

Fukuyama, Hiroshima, Japan

Social Medical Care Corporation Hose-kai Marunouchi Hospital

🇯🇵

Matsumoto-City, Nagano Prefecture, Japan

Omi Medical Center

🇯🇵

Kusatsu, Shiga, Japan

Juntendo University Hospital

🇯🇵

Bunkyo-ku, Tokyo, Japan

Fukuwa Clinic

🇯🇵

Chuo-ku, Tokyo, Japan

The Catholic University of Korea, St. Vincent's Hospital

🇰🇷

Gyeonggi-do, Korea, Republic of

Korea University Ansan Hospital

🇰🇷

Ansan, Gyeonggi-do, Korea, Republic of

Sekino Hospital

🇯🇵

Toshima-ku, Tokyo, Japan

Fukui-Ken Saiseikai Hospital

🇯🇵

Fukui, Japan

Japanese Red Cross Kumamoto Hospital

🇯🇵

Kumamoto, Japan

Gachon University Gil Medical Center

🇰🇷

Incheon, Korea, Republic of

Kyungpook National University Hospital

🇰🇷

Daegu, Korea, Republic of

Inha University Hospital

🇰🇷

Incheon, Korea, Republic of

Korea University Guro Hospital

🇰🇷

Seoul, Korea, Republic of

Hospital Cayetano Heredia

🇵🇪

San Martin de Porres, Lima, Peru

Hospital Nacional Adolfo Guevara Velasco

🇵🇪

Cusco, Peru

NZOZ Vitamed

🇵🇱

Bydgoszcz, Poland

Centro Hospitalar Vila Nova de Gaia/Espinho, E.P.E.

🇵🇹

Vila Nova de Gaia, Portugal

PULMO-MEDIK s.r.o., Pneumologicko-ftizeologicka ambulancia

🇸🇰

Bojnice, Slovakia

Medak s.r.o., Gastroenterologicka ambulancia

🇸🇰

Bratislava, Slovakia

MUDr. Viliam Cibik, PhD, s.r.o.

🇸🇰

Pruske, Slovakia

Synexus Polska Sp. z o.o. Oddzial w Gdyni

🇵🇱

Gdynia, Poland

SYNEXUS Polska Sp. z o.o. Oddzial w Katowicach

🇵🇱

Katowice, Poland

Synexus Polska Sp. z o.o. Oddział w Poznaniu

🇵🇱

Poznan, Poland

Synexus Polska Sp. z o.o. Oddzial we Wroclawiu

🇵🇱

Wroclaw, Poland

Hospital Senhora de Oliveira - Guimaraes, E.P.E.

🇵🇹

Guimaraes, Portugal

Niepubliczny Zaklad Opieki Zdrowotnej Salmed S. C.

🇵🇱

Leczna, Poland

Dionea, s.r.o.

🇸🇰

Nove Zamky, Slovakia

MEDIPA, s.r.o.

🇸🇰

Piestany, Slovakia

Plucna ambulancia Hrebenar s.r.o.

🇸🇰

Spisska Nova Ves, Slovakia

SPAOLO s.r.o., Ambulancia vnutorneho lekarstva

🇸🇰

Stara Tura, Slovakia

Privatna urologicka ambulancia, s.r.o.

🇸🇰

Trencin, Slovakia

Fakutna nemocnica Trnava

🇸🇰

Trnava, Slovakia

EAP Centelles

🇪🇸

Centelles, Barcelona, Spain

Oak Tree Surgery

🇬🇧

Liskeard, Cornwall, United Kingdom

Knowle House Surgery

🇬🇧

Plymouth, Devon, United Kingdom

Layton Medical Centre

🇬🇧

Blackpool, Lancashire, United Kingdom

University Hospitals of Leicester NHS Trust

🇬🇧

Leicester, Leicestershire, United Kingdom

Revival Research Institute, LLC

🇺🇸

Sterling Heights, Michigan, United States

UCLA CTRC Outpatient Unit

🇺🇸

Los Angeles, California, United States

Snake River Research, PLLC

🇺🇸

Idaho Falls, Idaho, United States

Louis Stokes Cleveland VA Medical Center

🇺🇸

Cleveland, Ohio, United States

Velocity Clinical Research, Inc.

🇺🇸

Cleveland, Ohio, United States

OhioHealth Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

Remington-Davis, Incorporated

🇺🇸

Columbus, Ohio, United States

St. Vincent Hospital & Health Care Center

🇺🇸

Indianapolis, Indiana, United States

Finlay Medical Research

🇺🇸

Miami, Florida, United States

Doctors Research Institute

🇺🇸

Miami, Florida, United States

Acevedo Clinical Research Associates

🇺🇸

Miami, Florida, United States

Duke University Hospital Investigational Drug Services (IDS) Pharmacy

🇺🇸

Durham, North Carolina, United States

VA Loma Linda Healthcare System Research Pharmacy

🇺🇸

Loma Linda, California, United States

Edward Hines Jr VA Hospital

🇺🇸

Hines, Illinois, United States

Kentucky Pediatric/Adult Research

🇺🇸

Bardstown, Kentucky, United States

Rochester Clinical Research

🇺🇸

Rochester, New York, United States

PMG Research of Raleigh, LLC d/b/a PMG Research of Cary

🇺🇸

Cary, North Carolina, United States

Washington University School of Medicine

🇺🇸

Saint Louis, Missouri, United States

PMG Research of Wilmington, LLC

🇺🇸

Wilmington, North Carolina, United States

Aultman Cardiology Clinical Trials

🇺🇸

Canton, Ohio, United States

University of Cincinnati Medical Center

🇺🇸

Cincinnati, Ohio, United States

University Of Cincinnati-Internal Medicine Division of Digestive Diseases

🇺🇸

Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center

🇺🇸

Cleveland, Ohio, United States

Great Lakes Medical Research LLC

🇺🇸

Mentor, Ohio, United States

Riverside Methodist Hospital

🇺🇸

Columbus, Ohio, United States

VA Pittsburgh Healthcare System

🇺🇸

Pittsburgh, Pennsylvania, United States

Synexus US, LP

🇺🇸

Dallas, Texas, United States

Wenatchee Valley Hospital & Clinics

🇺🇸

Wenatchee, Washington, United States

Virginia Research Center LLC

🇺🇸

Midlothian, Virginia, United States

J Lewis Research, Incorporated

🇺🇸

Salt Lake City, Utah, United States

Alliance for Multispecialty Research, LLC

🇺🇸

Wichita, Kansas, United States

Phoenix VA Health Care System

🇺🇸

Phoenix, Arizona, United States

Phoenix Clinical LLC

🇺🇸

Phoenix, Arizona, United States

Columbia Research Group, Inc.

🇺🇸

Portland, Oregon, United States

VA Portland Healthcare System

🇺🇸

Portland, Oregon, United States

Mayo Clinic

🇺🇸

Rochester, Minnesota, United States

Barrett Clinic

🇺🇸

Omaha, Nebraska, United States

North Alabama Research Center, LLC

🇺🇸

Athens, Alabama, United States

Clinical Research Institute of Arizona, LLC

🇺🇸

Surprise, Arizona, United States

Premier Health Research Center, LLC

🇺🇸

Downey, California, United States

Usborne Family Medicine

🇺🇸

Covina, California, United States

Baptist Health Center for Clinical Research

🇺🇸

Little Rock, Arkansas, United States

California Kidney Specialist

🇺🇸

Covina, California, United States

MedPharmics, LLC

🇺🇸

Metairie, Louisiana, United States

The Pain Center of Arizona

🇺🇸

Phoenix, Arizona, United States

Hope Research Institute

🇺🇸

Phoenix, Arizona, United States

Kaiser Permanente Roseville

🇺🇸

Roseville, California, United States

VA Long Beach Healthcare System

🇺🇸

Long Beach, California, United States

Baptist Health Rehabilitation Institute

🇺🇸

Little Rock, Arkansas, United States

Arkansas Gastroenterology

🇺🇸

North Little Rock, Arkansas, United States

Paradigm Clinical Research Centers, Inc.

🇺🇸

Redding, California, United States

VA Northern California Health Care System

🇺🇸

Mather, California, United States

Kaiser Permanente Walnut Creek

🇺🇸

Walnut Creek, California, United States

Optimus U. Corp.

🇺🇸

Miami, Florida, United States

Breakthrough Clinical Trials

🇺🇸

San Bernardino, California, United States

Southeast Clinical Research

🇺🇸

Chiefland, Florida, United States

Medical Research Center of Connecticut, LLC

🇺🇸

Hamden, Connecticut, United States

Next Phase Research Alliance

🇺🇸

Miami, Florida, United States

Christie Clinic, LLC

🇺🇸

Champaign, Illinois, United States

Omega Research Consultants, LLC

🇺🇸

DeBary, Florida, United States

Innovative Research of West FL., Inc.

🇺🇸

Clearwater, Florida, United States

Indago Research & Health Center, Inc

🇺🇸

Hialeah, Florida, United States

Solaris Clinical Research

🇺🇸

Meridian, Idaho, United States

Clinical Neuroscience Solutions,Inc.

🇺🇸

Jacksonville, Florida, United States

Barnes-Jewish Hospital

🇺🇸

Saint Louis, Missouri, United States

Advanced Clinical Research

🇺🇸

Meridian, Idaho, United States

St. Vincent Hospital and Health Care Center

🇺🇸

Indianapolis, Indiana, United States

Luminis Health Anne Arundel Medical Center Infusion Center

🇺🇸

Annapolis, Maryland, United States

Mayo Clinic Rochester, Methodist Hospital Campus

🇺🇸

Rochester, Minnesota, United States

Tandem Clinical Research, LLC

🇺🇸

Marrero, Louisiana, United States

Barnes Jewish Hospital

🇺🇸

Saint Louis, Missouri, United States

UC Health Physicians Office Clifton

🇺🇸

Cincinnati, Ohio, United States

New Mexico VA Healthcare System

🇺🇸

Albuquerque, New Mexico, United States

Center for Advanced Medicine

🇺🇸

Saint Louis, Missouri, United States

Center For Clinical Studies

🇺🇸

Saint Louis, Missouri, United States

Aa Mrc Llc

🇺🇸

Flint, Michigan, United States

PMG Research of Charlotte, LLC

🇺🇸

Charlotte, North Carolina, United States

Waterway Primary Care LLC DBA Tabor City Family Medicine

🇺🇸

Tabor City, North Carolina, United States

Durham VAMC

🇺🇸

Durham, North Carolina, United States

Sterling Research Group, Ltd.

🇺🇸

Cincinnati, Ohio, United States

Meridian Clinical Research, LLC

🇺🇸

Endwell, New York, United States

Bozeman Health GI Clinic

🇺🇸

Bozeman, Montana, United States

Meridian Clinical Research LLC

🇺🇸

Binghamton, New York, United States

Capital Area Research, LLC

🇺🇸

Camp Hill, Pennsylvania, United States

Drexel University College of Medicine

🇺🇸

Philadelphia, Pennsylvania, United States

Kaiser Permanente Center For Health Research

🇺🇸

Portland, Oregon, United States

Liberty Family Practice

🇺🇸

Erie, Pennsylvania, United States

PMG Research of Hickory, LLC

🇺🇸

Hickory, North Carolina, United States

Paratus Clinical Pty Ltd

🇦🇺

Kanwal, New South Wales, Australia

Main Street Physician's Care - Waterway

🇺🇸

Little River, South Carolina, United States

PharmQuest

🇺🇸

Greensboro, North Carolina, United States

Wake Research Associates, LLC

🇺🇸

Raleigh, North Carolina, United States

Aultman Hospital

🇺🇸

Canton, Ohio, United States

PriMED Clinical Research

🇺🇸

Dayton, Ohio, United States

Lehigh Valley Health Network/Network Office of Research and Innovation

🇺🇸

Allentown, Pennsylvania, United States

PMG Research of Raleigh, LLC

🇺🇸

Raleigh, North Carolina, United States

DM Clinical Research

🇺🇸

Tomball, Texas, United States

Martin Diagnostic Clinic

🇺🇸

Tomball, Texas, United States

Westminster Family Medicine

🇺🇸

Erie, Pennsylvania, United States

Kelsey Research Foundation

🇺🇸

Houston, Texas, United States

Clinical Alliance for Research & Education - Infectious Diseases, LLC

🇺🇸

Annandale, Virginia, United States

Kelsey-Seybold Clinic

🇺🇸

Houston, Texas, United States

Diagnostics Research Group

🇺🇸

San Antonio, Texas, United States

South Texas Veterans Healthcare System, Audie L Murphy Hospital

🇺🇸

San Antonio, Texas, United States

University of Texas Medical Branch

🇺🇸

Galveston, Texas, United States

Clinical Trials of Texas, Inc.

🇺🇸

San Antonio, Texas, United States

University of North Texas Health Science Center at Fort Worth

🇺🇸

Fort Worth, Texas, United States

Universal Research Group, LLC

🇺🇸

Tacoma, Washington, United States

Salem VAMC

🇺🇸

Salem, Virginia, United States

Synexus US, dba Research Across America

🇺🇸

Mesquite, Texas, United States

LinQ Research, LLC

🇺🇸

Pearland, Texas, United States

North Texas Infectious Diseases Consultants, P.A.

🇺🇸

Dallas, Texas, United States

Texas Center for Drug Development, Inc.

🇺🇸

Houston, Texas, United States

J. Lewis Research, Inc./Foothill Family Clinic

🇺🇸

Salt Lake City, Utah, United States

MultiCare Institute for Research & Innovation

🇺🇸

Tacoma, Washington, United States

Sanatorio Británico S.A.

🇦🇷

Rosario, Santa FE, Argentina

Advanced Clinical Research/Gut Whisperer

🇺🇸

Riverton, Utah, United States

Frandsen Family Medicine DBA Sound Medical Research

🇺🇸

Port Orchard, Washington, United States

"MHAT- Dr. Hristo Stambolski" EOOD

🇧🇬

Kazanlak, Bulgaria

UMHAT "Dr. Georgi Stranski" EAD, Second Psychiatric Clinic of general psychiatry and dependence

🇧🇬

Pleven, Bulgaria

Linear Clinical Research

🇦🇺

Nedlands, Western Australia, Australia

UMHAT "Sveti Georgi" EAD

🇧🇬

Plovdiv, Bulgaria

''Medical Center-1-Sevlievo'' EOOD

🇧🇬

Sevlievo, Bulgaria

Eastern Health - Box Hill Hospital

🇦🇺

Box Hill, Victoria, Australia

MHAT "Sv. Nikolay Chudotvorets" EOOD

🇧🇬

Lom, Bulgaria

Mater Misericordiae Ltd & Mater Medical Research Institute Ltd

🇦🇺

South Brisbane, Queensland, Australia

Barwon Health

🇦🇺

Geelong, Victoria, Australia

MC Medica Plus OOD

🇧🇬

Veliko Tarnovo, Bulgaria

Emeritus Research

🇦🇺

Camberwell, Victoria, Australia

CHU de Liège - Domaine universitaire du Sart Tilman

🇧🇪

Liege, Belgium

Acibadem City Clinic Tokuda Ead

🇧🇬

Sofia, Bulgaria

Institut Jules Bordet

🇧🇪

Brussels, Belgium

UZ Leuven

🇧🇪

Leuven, Belgium

MHAT ''Sv.Ivan Rilski-Kozloduy'' EOOD; Internal Department

🇧🇬

Kozloduy, Bulgaria

"SHATPD-Troyan" EOOD

🇧🇬

Troyan, Bulgaria

"Center for Mental Health - Ruse" EOOD

🇧🇬

Ruse, Bulgaria

SHATPPD Dr. Dimitar Gramatikov - Ruse EOOD

🇧🇬

Ruse, Bulgaria

MHAT -Silistra AD

🇧🇬

Silistra, Bulgaria

MC 'Cardiohelp' EOOD

🇧🇬

Sofia, Bulgaria

Vancouver Coastal Health Research Institution-clinical research unit-Diamond Health Care Centre

🇨🇦

Vancouver, British Columbia, Canada

The Ottawa Hospital General Campus

🇨🇦

Ottawa, Ontario, Canada

Instituto de Coloproctologia ICO

🇨🇴

Medellin, Antioquia, Colombia

Slezska Nemocnice v Opave, prispevkova organizace

🇨🇿

Opava, Czechia

Centro de Investigaciones - MedPlus Centro de Recuperación Integral S.A.S.

🇨🇴

Bogota, D.c., Colombia

Policska nemocnice s.r.o.,

🇨🇿

Policka, Czechia

SIBAmed Studienzentrum GmbH & Co.KG

🇩🇪

Leipzig, Germany

Gemeinschaftspraxis Dr. med. Heidrun Taeschner und Dr. med. Susanne Bonigut

🇩🇪

Leipzig, Germany

Ordinace vseobecneho praktickeho lekare

🇨🇿

Benatky nad Jizerou, Czechia

Oblastni nemocnice Pribram, a.s.

🇨🇿

Pribram I., Czechia

CIC Vaccinologie Cochin- Pasteur 1417

🇫🇷

Paris, France

EUGASTRO GmbH/ Praxis

🇩🇪

Leipzig, Germany

Budapesti Szent Ferenc Korhaz, Kardiologiai Rehabilitacios Osztaly

🇭🇺

Budapest, Hungary

Klinikum Wuerzburg Mitte gGmbH

🇩🇪

Wuerzburg, Germany

Bajai Szent Rokus Korhaz, II Belgyogyaszat

🇭🇺

Baja, Hungary

ClinTrial Audit Kft., Klinikai Farmakologiai Intezet, Vedooltasi Ambulancia

🇭🇺

Debrecen, Hungary

Somogy Megyei Kaposi Mor Oktato Korhaz, Infektologiai Osztaly

🇭🇺

Kaposvar, Hungary

Tokai Memorial Hospital

🇯🇵

Kasugai, Aichi, Japan

Daido Clinic

🇯🇵

Nagoya, Aichi, Japan

Kamiiida daiichi General Hospital

🇯🇵

Nagoya, Aichi, Japan

Nozaki Tokushukai Hospital

🇯🇵

Daito, Osaka, Japan

Medical Corporation Tokushukai Koga General Hospital

🇯🇵

Koga, Ibaraki, Japan

Saga-Ken Medical Centre Koseikan

🇯🇵

Saga, Japan

Yonsei University Wonju Severance Christian Hospital

🇰🇷

Wonju-si, Gangwon-do, Korea, Republic of

Hallym University Kangdong Sacred Heart Hospital

🇰🇷

Seoul, Korea, Republic of

Mito Kyodo General Hospital

🇯🇵

Mito, Ibaraki, Japan

Yaizu City Hospital

🇯🇵

Yaizu, Shizuoka, Japan

Yokosuka Kyosai Hospital

🇯🇵

Yokosuka, Kanagawa, Japan

Osaki Citizen Hospital

🇯🇵

Osaki, Miyagi, Japan

Asan Medical Center

🇰🇷

Songpa-gu, Seoul, Korea, Republic of

Dong-A University Hospital

🇰🇷

Busan, Korea, Republic of

Korea University Anam Hospital

🇰🇷

Seoul, Korea, Republic of

Samsung Medical Center

🇰🇷

Seoul, Korea, Republic of

Clinica Internacional S.A

🇵🇪

Lima, Peru

Synexus Polska Sp. z o.o Oddzial w Gdansku

🇵🇱

Gdansk, Poland

Synexus Polska Sp. z o.o. Oddzial w Warszawie

🇵🇱

Warszawa, Poland

MUDr. Zakova, s.r.o.

🇸🇰

Trencin, Slovakia

Hallym University Kangnam Sacred Heart Hospital

🇰🇷

Seoul, Korea, Republic of

Centro Hospitalar do Baixo Vouga, E.P.E.

🇵🇹

Aveiro, Portugal

Hospital de Braga

🇵🇹

Braga, Portugal

Parc de Salut Mar- Hospital del Mar

🇪🇸

Barcelona, Spain

Complejo Hospitalario Universitario A Coruna

🇪🇸

A Coruna, Spain

Stalerg, s.r.o.

🇸🇰

Kosice, Slovakia

Medilex s.r.o., Interna ambulancia

🇸🇰

Rimavska Sobota, Slovakia

Avdelningen for kliniska provningar, S-huset

🇸🇪

Orebro, Sweden

Kaohsiung Veterans General Hospital

🇨🇳

Kaohsiung City, Taiwan (r.o.c.), Taiwan

The Alverton Practise, St Clare Medical Centre

🇬🇧

Penzance, Cornwall, United Kingdom

Infektionskliniken, Malarsjukhuset

🇸🇪

Eskilstuna, Sweden

Sahlgrenska Universitetssjukhuset - Ostra Sjukhuset

🇸🇪

Goteborg, Sweden

Karolinska Trial Alliance, KTA Prim Sabbatsbergs sjukhus

🇸🇪

Stockholm, Sweden

National Taiwan University Hospital

🇨🇳

Taipei, Taiwan

Hospital Universitario Fundacion Jimenez Diaz

🇪🇸

Madrid, Spain

Fowey River Practice

🇬🇧

Fowey, Cornwall, United Kingdom

Rame Group Practice, Rame Medical Ltd.

🇬🇧

Torpoint, Cornwall, United Kingdom

Heart of England NHS Foundation Trust

🇬🇧

Birmingham, WEST Midlands, United Kingdom

Far Eastern Memorial Hospital

🇨🇳

New Taipei City, Taiwan

Gothia Forum CTC/Sahlgrenska Universitetssjukhuset

🇸🇪

Göteborg, Sweden

Stockport Nhs Foundation Trust

🇬🇧

Stockport, Cheshire, United Kingdom

Newcastle upon Tyne Hospitals NHS Foundation trust

🇬🇧

Newcastle upon Tyne, United Kingdom

St James University Hospital

🇬🇧

Leeds, United Kingdom

Royal Devon & Exeter Hospital

🇬🇧

Exeter, Devon, United Kingdom

NHS Lothian, Western General Hospital

🇬🇧

Edinburgh, Midlothian, United Kingdom

Hospital Clinic de Barcelona

🇪🇸

Barcelona, Spain

Hospital Universitario de la Princesa

🇪🇸

Madrid, Spain

Hospital de la Santa Creu i Sant Pau

🇪🇸

Barcelona, Spain

Hospital Universitario Gregorio Marañón

🇪🇸

Madrid, Spain

Hospital Universitario Ramon y Cajal

🇪🇸

Madrid, Spain

Hospital Universitari i Politecnic La Fe

🇪🇸

Valencia, Spain

Hospital Universitario Virgen Macarena

🇪🇸

Sevilla, Spain

One Community Health

🇺🇸

Sacramento, California, United States

Kaiser Permanente Sacramento

🇺🇸

Sacramento, California, United States

CTSC Clinical Research Center

🇺🇸

Sacramento, California, United States

Lawrence J. Ellison Ambulatory Care Center

🇺🇸

Sacramento, California, United States

University of California, Davis Medical Center

🇺🇸

Sacramento, California, United States

Kaiser Permanente South Sacramento

🇺🇸

Sacramento, California, United States

Clinical Neuroscience Solutions, Inc. dba CNS Healthcare

🇺🇸

Orlando, Florida, United States

Clinical Trial Center University of Colorado Denver, School of Medicine

🇺🇸

Aurora, Colorado, United States

HMD Research LLC

🇺🇸

Orlando, Florida, United States

University of Colorado Clinical & Translational Research Center Clinic

🇺🇸

Aurora, Colorado, United States

University of Colorado Denver, School of Medicine

🇺🇸

Aurora, Colorado, United States

University of Colorado Clinical & Translational Research Center Outpatient Clinic

🇺🇸

Aurora, Colorado, United States

University of Colorado Department of AIP 2. Pharmacy Bulk Storage

🇺🇸

Aurora, Colorado, United States

VA Ann Arbor Healthcare System

🇺🇸

Ann Arbor, Michigan, United States

PMG Research of Winston-Salem, LLC

🇺🇸

Winston-Salem, North Carolina, United States

Progressive Medicine of the Triad, LLC

🇺🇸

Winston-Salem, North Carolina, United States

VA Loma Linda Healthcare System

🇺🇸

Loma Linda, California, United States

Coastal Clinical Research, LLC, An AMR Company

🇺🇸

Mobile, Alabama, United States

Long Beach Clinical Trials Services, Inc.

🇺🇸

Long Beach, California, United States

Academic Medical Research Institute

🇺🇸

Los Angeles, California, United States

Ronald Reagan UCLA Medical Center

🇺🇸

Los Angeles, California, United States

Long Beach Clinical Trials

🇺🇸

Long Beach, California, United States

Covigilant Research, LLC

🇺🇸

Rancho Mirage, California, United States

Covigilant Research LLC

🇺🇸

Riverside, California, United States

Veterans Affairs Palo Alto Health Care System

🇺🇸

Palo Alto, California, United States

Kaiser Permanente San Jose

🇺🇸

San Jose, California, United States

VA San Diego Healthcare System

🇺🇸

San Diego, California, United States

VA Loma Linda Healthcare System Ambulatory Care System

🇺🇸

Redlands, California, United States

Alta California Medical Group

🇺🇸

Simi Valley, California, United States

Kaiser Permanente Santa Clara

🇺🇸

Santa Clara, California, United States

California Kidney Specialists

🇺🇸

San Dimas, California, United States

Gastroenterology Center of Connecticut, PC

🇺🇸

Hamden, Connecticut, United States

Florida Sleep Disorder Center of Brandon

🇺🇸

Brandon, Florida, United States

Accel Research Sites - DeLand Clinical Research Unit

🇺🇸

DeLand, Florida, United States

Teradan Clinical Trials

🇺🇸

Brandon, Florida, United States

Alliance for Multispecialty Reseach, LLC

🇺🇸

Coral Gables, Florida, United States

Springfield Clinic Infectious Diseases

🇺🇸

Springfield, Illinois, United States

Clinical Research Atlanta

🇺🇸

Stockbridge, Georgia, United States

Atlanta VA Medical Center

🇺🇸

Decatur, Georgia, United States

Meridian Clinical Research

🇺🇸

Sioux City, Iowa, United States

Infectious Disease of Indiana, PSC

🇺🇸

Carmel, Indiana, United States

Community Clinical Research Center

🇺🇸

Anderson, Indiana, United States

St. Vincent Outpatient Treatment Center

🇺🇸

Carmel, Indiana, United States

Deaconess Clinic Mt. Pleasant

🇺🇸

Evansville, Indiana, United States

MOC Research

🇺🇸

Mishawaka, Indiana, United States

Barnum Medical Research Inc

🇺🇸

Natchitoches, Louisiana, United States

MedPharmics

🇺🇸

Gulfport, Mississippi, United States

Center for Outpatient Health

🇺🇸

Saint Louis, Missouri, United States

Duke Early Phase Clinical Research

🇺🇸

Durham, North Carolina, United States

PMG Research of Salisbury, LLC

🇺🇸

Salisbury, North Carolina, United States

Lillestol Research LLC

🇺🇸

Fargo, North Dakota, United States

PMG Research of Rocky Mount, LLC

🇺🇸

Rocky Mount, North Carolina, United States

IPS Research Company

🇺🇸

Oklahoma City, Oklahoma, United States

Velocity Clinical Research, Providence

🇺🇸

East Greenwich, Rhode Island, United States

PMG Research, Inc. d/b/a PMG Research of Knoxville

🇺🇸

Knoxville, Tennessee, United States

Texas Health Care, PLLC

🇺🇸

Fort Worth, Texas, United States

Coastal Carolina Research Center

🇺🇸

North Charleston, South Carolina, United States

Ventavia Research Group, LLC

🇺🇸

Fort Worth, Texas, United States

Preferred Primary Care Physicians, Inc.

🇺🇸

Uniontown, Pennsylvania, United States

Hospital Nuestra Senora de la Misericordia

🇦🇷

Cordoba, Argentina

Australian Clinical Research Network

🇦🇺

Maroubra, Australia

Hospital Aleman

🇦🇷

C.a.b.a., Buenos Aires, Argentina

Centro Médico Dra. De Salvo

🇦🇷

C.a.b.a., Buenos Aires, Argentina

Austrials Pty Ltd

🇦🇺

Sherwood, Queensland, Australia

Maroubra Medical Centre

🇦🇺

Maroubra, New South Wales, Australia

University Clinic Pharmacy

🇦🇺

Westmead, New South Wales, Australia

Westmead Hospital

🇦🇺

Westmead, New South Wales, Australia

MHAT ''Sveta Petka" AD

🇧🇬

Vidin, Bulgaria

Q & T Research Outaouais Inc.

🇨🇦

Gatineau, Quebec, Canada

Intermed Groupe Santé

🇨🇦

Chicoutimi, Quebec, Canada

Centre Integre de Sante et de Services Sociaux de la Monteregie- Center- Hopital Charles LeMoyne

🇨🇦

Greenfield Park, Quebec, Canada

Manna Research Inc. (Toronto)

🇨🇦

Toronto, Ontario, Canada

CIUSSS de l'Estrie - CHUS

🇨🇦

Sherbrooke, Quebec, Canada

Centre Integre Universitaire de Santé et de Services Sociaux de la Mauricie et du Centre du Québec

🇨🇦

Trois-Rivieres, Quebec, Canada

Centre de recherche du CHU de Quebec-Universite Laval

🇨🇦

Quebec, Canada

Centre de recherche Saint-Louis

🇨🇦

Quebec, Canada

ALPHA Recherche Clinique

🇨🇦

Quebec, Canada

Centro de Investigacion Clínica del Sur

🇨🇱

Temuco, IX Region DE LA Araucania, Chile

Psicomed Esudios Medicos

🇨🇱

Antofagasta, Region DE Antofagasta, Chile

Hospital Dr. Hernan Henriquez Aravena

🇨🇱

Temuco, Region DE LA Araucania, Chile

Biomedica Research Group

🇨🇱

Santiago, Región Metropolitana, Chile

Fundacion Arriaran

🇨🇱

Santiago, Región Metropolitana, Chile

Fundacion Centro de Investigacion Clinica - CIC

🇨🇴

Medellin, Antioquia, Colombia

Clinica de la Costa Ltda.

🇨🇴

Barranquilla, Atlantico, Colombia

Hospital Pablo Tobon Uribe

🇨🇴

Medellin, Antioquia, Colombia

Kokkola Vaccine Research Clinic

🇫🇮

Kokkola, Finland

Asociación IPS Médicos Internistas de Caldas

🇨🇴

Manizales, Caldas, Colombia

Fundación Cardiomet CEQUIN

🇨🇴

Armenia, Quindío, Colombia

Fundacion Valle del Lili

🇨🇴

Cali, Valle DEL Cauca, Colombia

Doktor Brno s.r.o.

🇨🇿

Brno, Czech, Czechia

Nemocnice Kyjov, prispevkova organizace, Infekcni oddeleni

🇨🇿

Kyjov, Czechia

Sarkamed s.r.o.

🇨🇿

Slany, Czechia

Interna a kardiologie s.r.o.

🇨🇿

Roznov pod Radhostem, Czechia

Krajska zdravotni, a.s., Masarykova nemocnice Usti nad Labem

🇨🇿

Usti nad Labem, Czechia

Fakultni nemocnice v Motole

🇨🇿

Praha 5, Czechia

Nemocnice Slany, p.o.

🇨🇿

Slany, Czechia

Helsinki University Central Hospital

🇫🇮

Helsinki, Finland

CHU DIJON BOURGOGNE- Hopital Francois Mitterrand

🇫🇷

Dijon cedex, France

Pori Vaccine Research Clinic

🇫🇮

Pori, Finland

Turku Vaccine Research Clinic

🇫🇮

Turku, Finland

Oulu Vaccine Research Clinic

🇫🇮

Oulu, Finland

Tampere Vaccine Research Clinic

🇫🇮

Tampere, Finland

Hopital Nord-CHU Saint Etienne

🇫🇷

Saint Priest en Jarez, France

Emovis GmbH

🇩🇪

Berlin, Germany

CHRU de Tours- Hopital Bretonneau

🇫🇷

Tours Cedex 09, France

MECS Cottbus GmbH

🇩🇪

Cottbus, Germany

Universitaetsklinikum Essen, Klinik fuer Infektiologie

🇩🇪

Essen, Germany

Diabetologische Gemeinschaftspraxis Dr. Schaper & Dr. Faulmann

🇩🇪

Dresden, Germany

Hospital Garcia de Orta

🇵🇹

Almada, Portugal

Centro de Investigaciones Biomédicas - CIBIOM/Clinica Peruano Americana S.A

🇵🇪

Trujillo, La Libertad, Peru

KM Management spol. s.r.o., Gastroenterologicke a hepatologicke centrum Nitra

🇸🇰

Nitra, Slovakia

Hospital Universitari de Bellvitge

🇪🇸

Hospitalet de Llobregat, Barcelona, Spain

Malcom Randall VA Medical Center Investigational Drug Services

🇺🇸

Gainesville, Florida, United States

Malcom Randall VA Medical Center

🇺🇸

Gainesville, Florida, United States

Ochsner Center for Primary Care and Wellness

🇺🇸

New Orleans, Louisiana, United States

Ochsner Clinic Foundation

🇺🇸

New Orleans, Louisiana, United States

Medical Research South, LLC

🇺🇸

Charleston, South Carolina, United States

Tekton Research, Inc.

🇺🇸

Austin, Texas, United States

East-West Medical Research Institute

🇺🇸

Honolulu, Hawaii, United States

Central Kentucky Research Associates, LLC

🇺🇸

Lexington, Kentucky, United States

Medical Affiliated Research Center, Inc.

🇺🇸

Huntsville, Alabama, United States

Kaiser Permanente Daly City

🇺🇸

Daly City, California, United States

Sundance Clinical Research

🇺🇸

Saint Louis, Missouri, United States

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