STAND UP - Sedentary Behaviour in Older Adults: Investigating a New Therapeutic Paradigm Work Package 3: Investigating the Effect of Sedentary Time, Reduced Sedentary Time and Increased Light-intensity Physical Activity on Metabolic and Psychological Health in Older Adults
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Older Adults
- Sponsor
- University of Leicester
- Enrollment
- 76
- Locations
- 2
- Primary Endpoint
- Insulin area under the curve
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
Research has shown that reducing the time spent sitting can reduce the risk of many diseases, such as diabetes and heart disease, and improve health. It is estimated that many older adults typically spend 70% of their waking day sitting, but little is known about whether reducing sitting promotes health and well-being in this age group. The aim of this research is to investigate the health effects of reducing sitting time by replacing it with short periods of standing or walking in adults over the age of 65.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Adults aged between 65 to 79 years inclusive
- •Able to walk (without any assistive devices and not requiring assistance from another person)
- •Ability to communicate in and understand English to participate in the informed consent process.
Exclusion Criteria
- •Regular purposeful exercise (≥75 minutes of self-reported vigorous exercise per week)
- •Inability to stand or undertake light ambulation
- •Psychological condition which limits participation in the study (e.g. dementia)
- •Inability to communicate or understand English
- •Steroid use
- •Use of glucose lowering medication
- •Inability to give informed consent
Outcomes
Primary Outcomes
Insulin area under the curve
Time Frame: 3 experimental intervention study visits over an estimated period of 1 month
Samples will be batched and analysed at the end of the study within a certified research laboratory at the Institute of Cardiovascular and Medical Sciences (ICAMS), University of Glasgow. Samples collected at the Leicester Diabetes Centre will be sent by courier in specialist containers and packed with dry ice.
Secondary Outcomes
- Glucose area under the curve(3 experimental intervention study visits over an estimated period of 1 month)
- Karolinska Sleepiness Scale (1-9)(3 experimental intervention study visits over an estimated period of 1 month)
- 1H NMR Metabolomics spectroscopy(3 experimental intervention study visits over an estimated period of 1 month)
- Felt Arousal Scale (0-5)(3 experimental intervention study visits over an estimated period of 1 month)
- Semantic Verbal Fluency Test (number of items)(3 experimental intervention study visits over an estimated period of 1 month)
- Trail Making Tests A (time to complete)(3 experimental intervention study visits over an estimated period of 1 month)
- Triglyceride area under the curve(3 experimental intervention study visits over an estimated period of 1 month)
- Feeling Scale (-5 to +5)(3 experimental intervention study visits over an estimated period of 1 month)
- Rapid Visual Information Processing Test (number of sequences detected and errors)(3 experimental intervention study visits over an estimated period of 1 month)
- Hopkins Verbal Learning Test (number of words recalled)(3 experimental intervention study visits over an estimated period of 1 month)
- Trail Making Tests B (time to complete)(3 experimental intervention study visits over an estimated period of 1 month)
- Blood pressure(3 experimental intervention study visits over an estimated period of 1 month)