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临床试验/NCT03574233
NCT03574233Unknown不适用

Ultrasonography Guided Weaning Protocol Development to Predict Successful Weaning

Yonsei University1 个研究点 分布在 1 个国家目标入组 200 人开始时间: 2019年3月最近更新:
适应症

试验速览

阶段
不适用
入组人数
200
试验地点
1
主要终点
Investigation of ultrasound indices associated with the success or failure of mechanical ventilation weaning

研究概览

简要总结

The investigators aimed to develop integrated ultrasound guided mechanical weaning protocol in critically ill patients. The analysis will be taken (1) just before the spontaneous breathing trial in enrolled patients with mechanical ventilation and (2) in patients with tracheostomy who fail ventilator off.

详细描述

Prolonged mechanical ventilation is associated with higher ventilator-associated pneumonia and ventilator-associated lung injury, longer intensive care unit and hospital days, increased mortality, and higher medical costs. However, some patients are difficult to wean from invasive mechanical ventilation. Typically, the difficulty in transitioning patients to spontaneous breathing may be categorized as simple transition, difficult transition, and prolonged transition.

There are a lot of predictors for weaning failure such as cardiac dysfunction, increased respiratory rate, diaphragm dysfunction, rapid shallow breathing index and so on. However, weaning failure involves complicated mechanisms that are not solved by one cause. Recently, P. Mayo published a review paper on ultrasonography evaluation during the weaning process. The investigators need to pay attention to this paper. While lots of previous predictors cannot explain the reason, ultrasound evaluation is a process of finding the cause as well as prediction for weaning failure. However, The investigators need a more practical and standardized ultrasound protocols for how to wean invasive mechanical ventilation. "Ultrasonographic mechanical weaning protocol" should not comprise just one indicator, but include various indicators such as upper airway stenosis, heart function, the status of the lung and pleura, diaphragmatic function, Etc. This integrated ultrasound protocol will help in successful weaning of invasive mechanical ventilation.

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
18 Years 至 —(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • Invasive mechanical ventilation > 24 hours
  • Eligibility to weaning from mechanical ventilation

排除标准

  • Age < 18 years old
  • Severe skin lesions or infections that cannot perform ultrasound
  • Severe subcutaneous emphysema that cannot perform ultrasound
  • Patients who completed "Do-not-resuscitation" consents

结局指标

主要结局

Investigation of ultrasound indices associated with the success or failure of mechanical ventilation weaning

时间窗: within 48 hours

* Weaning success: stable without mechanical ventilator support during more than 48 hours * Weaning failure: unstable without mechanical ventilator support within 48 hours A) Type I respiratory failure: high flow oxygen support B) Type II respiratory failure: non-invasive ventilatory support C) Reintubation

次要结局

  • A) In-ICU mortality(90 days after Ultrasonography)
  • B) In-hospital mortality(90 days after Ultrasonography)
  • C) Ventilator free day(90 days after Ultrasonography)
  • D) ICU free day(90 days after Ultrasonography)

研究者

申办方类型
Other
责任方
Sponsor

研究点 (1)

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