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Clinical Trials/NCT07522723
NCT07522723
Not yet recruiting
Not Applicable

Clinical and Radiographic Assessment of Bio C Repair, Biodentine and Mineral Trioxide Aggregate Used As Pulpotomy Agents In Vital Immature Permanent Molars With Irreversible Pulpits. A Randomized Control Trial

Cairo University0 sites60 target enrollmentStarted: April 20, 2026Last updated:

Overview

Phase
Not Applicable
Status
Not yet recruiting
Enrollment
60
Primary Endpoint
Radiographic examination of complete apical closure

Overview

Brief Summary

The aim of this study is to assess Clinical and Radiographical effect of Bio C repair, Biodentine and Mineral Trioxide Aggregate when used as pulpotomy Agents in Immature Permanent Molars with Pulpits.

Study Design

Study Type
Interventional
Allocation
Randomized
Intervention Model
Parallel
Primary Purpose
Treatment
Masking
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

Eligibility Criteria

Ages
6 Years to 10 Years (Child)
Sex
All
Accepts Healthy Volunteers
Yes

Inclusion Criteria

  • Children aged 6-10 years with asymptomatic/symptomatic disease and having vital immature permanent posterior teeth with clinical exposure to dental caries of the pulp and bleeding.
  • Posterior teeth had deep caries with pulp exposure.
  • Posterior teeth that exhibited preoperative symptoms, such as referred pain, spontaneous pain or pain induced during thermal and cold sensitivity tests, with a range of symptoms that can last from seconds to hours compared to the control teeth.
  • Posterior teeth without prominent radiolucency in the furcation or periapical regions.
  • The posterior teeth could be restored.
  • Children with prior parental consent.

Exclusion Criteria

  • • (1) Patients with contraindications of the to-be-performed dental treatment.
  • (2) Teeth with completed VPT or RCT.
  • (3) Teeth with furcation, prominent radiolucency in the periapical regions, or external or internal resorption.
  • (4) Teeth with pulpitis attributed to tooth fracture, cracking, periodontitis or wedge-shaped defects.
  • (5) Teeth without any response to experiments of vitality. (
  • 6\) Teeth with formed root/closed apex.
  • (7) Teeth with edema, fistula and excessive mobility not associated with periodontal disease.

Arms & Interventions

Biodentine

Experimental

Pulpotomy using Biodentine in carious Immature permanent molars with irreversible pulpitis.

Intervention: Biodentine (Other)

MTA

Active Comparator

Mineral trioxide aggregate in carious Immature permanent molars with irreversible pulpitis.

Intervention: Biodentine (Other)

Bio C repair

Experimental

Pulpotomy using Bio C repair in carious Immature permanent molars with irreversible pulpitis.

Intervention: Bio C repair (Other)

MTA

Active Comparator

Mineral trioxide aggregate in carious Immature permanent molars with irreversible pulpitis.

Intervention: Bio C repair (Other)

Outcomes

Primary Outcomes

Radiographic examination of complete apical closure

Time Frame: 12 months

Digital Radiographic examination using visual examination of the teeth were made using the TPC paralleling device

Secondary Outcomes

  • The presence of Sinus or fistula(12 months)
  • tenderness associated with the tooth.(12 months)
  • Presence of pain(12 months)
  • The presence of Swelling(12 months)

Investigators

Sponsor Class
Other
Responsible Party
Principal Investigator
Principal Investigator

Alaa Yasser ElSheikh

PhD candidate

Cairo University

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