Identification of circulating microRNAs as a biomarker of mental stress
Not Applicable
- Conditions
- gastroesophageal reflux diseases
- Registration Number
- JPRN-UMIN000023771
- Lead Sponsor
- ational Cancer Center
- Brief Summary
We compared serum miRNA profiles between patients with GERD who responded to PPI therapy and those who were refractory to PPI therapy (assumed to have a strong predisposition to psychological stress), and were able to identify serum miRNAs that differed between the two groups.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 85
Inclusion Criteria
Not provided
Exclusion Criteria
- Pregnant women - Patient who has a history of surgical operation in the esophagus, the stomach, the liver, the gallbladder, or the pancreas - Patient who underwent Helicobacter pylori eradication therapy within the past 1 year - Patient who has on organic disease associated with gastrointestinal symptoms, such as malignant diseases - Patient who has an psychiatric illness, such as schizophrenia and depression
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The presence of circulating microRNAs which are associated with the severity of both mental stress (defined by HADS) and gastroesophageal reflux symptoms (defined by GerdQ)
- Secondary Outcome Measures
Name Time Method