Effect of Diode Laser as an additional therapy to Scaling and Root Planing on the levels of Gingival Crevicular Fluid (GCF) Endocan, Vascular Endothelial Growth Factor-A and Tumor Necrosis Factor-α in Aggressive Periodontitis.
Not Applicable
Completed
- Registration Number
- CTRI/2018/09/015583
- Lead Sponsor
- none
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 20
Inclusion Criteria
Systemically healthy patients, aged < 45 years and with at least 20 natural teeth in the oral cavity.
Patients affected and diagnosed with moderate to severe aggressive periodontitis as assessed with GI >1; probing depth (PD) > 5mm and clinical attachment loss (CAL) > 3mm with alveolar bone loss affecting > 30% of the teeth as detected on radiograph at the time of initial diagnosis.
Exclusion Criteria
Patients with medical disorders like cardiovascular, renal disease, etc.
Patients with recent history of acute or chronic infection.
Individuals with history of tobacco chewing and smoking.
Pregnant and lactating females.
Patients with history of periodontal therapy or antibiotic &/or anti-inflammatory medication within previous 6 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Improvement in GCF Endocan, Vascular Endothelial Growth Factor (VEGF-A) and Tumor Necrosis Factor-α (TNF-α) levels in aggressive periodontitis patientsTimepoint: 3 months
- Secondary Outcome Measures
Name Time Method Improvement in periodontal status i.e reduction in probing pocket depth and gain in clinical attachment level in aggressive periodontitis patientsTimepoint: 1 and 3 months