Remineralization of Dentine Caries Using Two Remineralizing Agents Which Are Nanosilver Fluoride and Casein phosphopeptides_amorphous Calcium Phosphate

Not Applicable

• Conditions: Dental Caries
• Interventions: Other: Sodium fluoride varnish; Other: Nanosilver fluoride; Other: Sodium fluoride with casein phosphopeptides amorphous calcium phosphate

• Registration Number: NCT04930458
• Lead Sponsor: University of Baghdad

Brief Summary

The study is randomized controlled trial ...The null hypothesis suggests that there is no significant difference between nanosilver fluoride and sodium fluoride with Casein phosphopeptides_amorphous calcium phosphate in the remineralization of dental caries.

Detailed Description

the patients will be randomly assigned to one of three study groups the first group is nanosilver fluoride,the second is casein phosphopeptides_amorphous calcium phosphate and the third is sodium fluoride as positive control..the three material will be applied in single application with no repetition ..follow up after one and three month ..the patient should have at least one carious lesion(ICDASII code 5)

Study Timeline

• Study First Submitted: 2021-05-31
• Study First Submitted QC: 2021-06-10
• Study First Posted: 2021-06-18
• Study Start: 2021-08-10
• Primary Completion: 2021-09-20
• Status Verified: 2022-05
• Last Update Submitted: 2022-05-16
• Last Update Posted: 2022-05-17
• Study Completion: 2022-06-20

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 135

Inclusion Criteria

Not provided

Exclusion Criteria

• sensitivity to Silver or other heavy-metal ions or any milk-related allergies and medical conditions involving the kidneys.
• The tooth was excluded if it had pulp exposure, abscess/fistula, sensitivity to percussion

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Sodium fluoride varnish group	Sodium fluoride varnish	Sodium fluoride varnish will be applied on carios lesion
Nanosilver fluoride group	Nanosilver fluoride	Nanosilver fluoride will be applied on carious lesion
Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate group	Sodium fluoride with casein phosphopeptides amorphous calcium phosphate	Sodium fluoride with casein phosphopeptides_Amorphous calcium phosphate will be applied on carios lesion

Primary Outcome Measures

Name	Time	Method
The incidence of patient with arrested dental caries using international caries detection and assessment system II(ICDAS II)	Change in the state of dental caries after one and 3 months after topical application of nanosilver fluoride and sodium fluoride with casein phosphopeptides amorphous calcium phosphate	The measure will be done using international caries detection and assessment system II (ICDAS II) criteria for diagnosing active and arrested caries by blunt probe.

Trial Locations

Locations (1)

Alhur alriyahi specialized dental center; 🇮🇶 Karbala, Iraq