A Protocol to Wean From Noninvasive Mechanical Ventilation
Trial Snapshot
- Phase
- Not Applicable
- Status
- Terminated
- Sponsor
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- The duration of noninvasive mechanical ventilation
Study Overview
Brief Summary
The investigators use a protocol to wean from noninvasive mechanical ventilation.
Detailed Description
Design: Prospective, randomized, controlled trial, with 2 groups: study (protocol weaning group) and control (clinicians' order weaning group). Setting: Respiratory Intensive Care Unit (RICU). Subjects: Patients >18 yr, noninvasive mechanical ventilation >24 hours. Interventions and measurements: Study group (weaning as the protocol) and control group (weaning as the clinicians' order); recording of clinical variables at admission and during RICU stay, and end-point variables (noninvasive mechanical ventilation day, RICU and hospital stay, RICU mortality. Expected results: the protocol group's noninvasive mechanical ventilation days is less than clinicians' order group.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Screening
- Masking
- None
Eligibility Criteria
- Ages
- 18 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •noninvasive mechanical ventilation > 24 hours.
- •age >18 years
Exclusion Criteria
- •severe cerebraI，heart，hepatic and renal faiIure.
- •facial or cranial trauma or surgery.
- •facial abnormalities.
- •recent gastric or esophageal surgery.
- •active upper gastrointestinal bleeding.
- •large amount of sputum with weak cough ability
- •lack of co-operation.
Outcomes
Primary Outcomes
The duration of noninvasive mechanical ventilation
Time Frame: from admission to ICU to discharge from it (average of 4 weeks)
The duration of noninvasive mechanical ventilation was measured from the patients admitted to ICU to discharged from it,an expected average of 4 weeks.
Secondary Outcomes
- The successful weaning rate(from admission to ICU to discharge from it (average of 4 weeks))
- The length of ICU days(from admission to ICU to discharge from it (average of 4 weeks))
- The intubation rate during the study(from admission to ICU to discharge from it (average of 4 weeks))
- The mortality during the study(from admission to ICU to discharge from it (average of 4 weeks))
Investigators
Duan jun
The first affiliated hospital of chong qing medical univercity
Chongqing Medical University