Diagnostic value of DECT scan compared to diagnostic needle aspiration DEteCTing gout, with or without a needle

Recruiting

Conditions: gout
10023213

Registration Number: NL-OMON42591

Lead Sponsor: Meander Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

Age > 18 years
Mono or oligo arthritis (2-3 swollen joints)
Indication for diagnostic aspiration of an inflamed joint in which gout is one of the possibilities

Exclusion Criteria

Polyarthritis (>=4 swollen joint);
Chrystal proven gout in history
Patient is on uric acid lowering therapy (Allopurinol, Benzbromaron, Febuxostat)
Hip arthritis
Metal or prosthesis of the inflamed joint
Highly suspicion of infectious arthritis
Pregnancy
Contra indication of joint aspiration (skin infection, hemophilia)
No informed consent

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The sensitivity and specificity (95% CI) of DECT scanning for the detection of<br /><br>MSU deposition will be calculated. The area under receiver operating<br /><br>characteristic curve (AUC-ROC) will be employed to evaluate the screening<br /><br>method*s performance.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Identify the clinical features and laboratory variables that affect the primary<br /><br>outcome measure of positive DECT scan for lesions suggestive of uric acid<br /><br>deposition in patients with acute mono or oligo arthritis.<br /><br>Establish the additive value of ultrasound guided joint aspiration in patients<br /><br>in whom the first aspirate demonstrated no microscopic MSU and /or no synovial<br /><br>fluid<br /><br>Establish the additive value of ultrasound guided joint aspiration of DECT<br /><br>lesions suggestive of gout in patients in whom the earlier aspirate(s)<br /><br>demonstrated no microscopic MSU and /or no synovial fluid.<br /><br>Cost effectiveness analysis of different diagnostic strategies.<br /><br>Patient satisfaction: What does the patient experience as the most<br /><br>patient-friendly way of diagnosing gout: DECT scan, ultrasound-guided joint<br /><br>aspiration or blind aspiration?</p><br>