VLDL-triglyceride Kinetics in Type 2 Diabetes
- Conditions
- Type 2 Diabetes
- Interventions
- Other: Hyperinsulinemic euglycemic glucose clamp
- Registration Number
- NCT01037647
- Lead Sponsor
- University of Aarhus
- Brief Summary
Type 2 diabetes is associated with diabetic dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in diabetic dyslipidemia.
The objective of this study was to investigate VLDL-TG kinetics and aspects of peripheral VLDL-TG metabolism, i.e. to what extent VLDL-TG associated fatty acids (FA) are oxidized or deposited in regional adipose tissue, in subjects with type 2 diabetes and healthy controls in the postabsorptive state and during acute hyperinsulinemia using ex-vivo labeled VLDL-TG tracers.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- Male
- Target Recruitment
- 22
Not provided
- Known disease except type 2 diabetes (type 2 diabetic subjects)
- Smoking
- Alcohol abuse
- Prescription medication expect oral antidiabetics (type 2 diabetic subjects)
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Arm && Interventions
Group Intervention Description Type 2 diabetic men Hyperinsulinemic euglycemic glucose clamp Men with type 2 diabetes Healthy men Hyperinsulinemic euglycemic glucose clamp Healthy men
- Primary Outcome Measures
Name Time Method VLDL-TG production and clearance rates
- Secondary Outcome Measures
Name Time Method VLDL-TG oxidation VLDL-TG subcutaneous adipose tissue storage
Trial Locations
- Locations (1)
Medical department M (Endocrinology and Diabetes), Aarhus University Hospital
🇩🇰Aarhus, DK, Denmark