Hepatic Insulin Sensitivity and Very Low Density Lipoprotein Triglyceride (VLDL-TG) Kinetics

Not Applicable

Completed

• Conditions: Obesity; Dyslipidemia
• Interventions: Other: Glucose clamp

• Registration Number: NCT01205750
• Lead Sponsor: University of Aarhus

Brief Summary

Obesity is associated with dyslipidemia, which is a major risk factor for coronary heart disease. Triglycerides (TG) and cholesterol are transported in the system of lipoproteins, and the metabolism of these lipids in plasma is closely interrelated. Evidence suggests that increased concentration of very low-density lipoprotein triglyceride (VLDL-TG) is a central pathophysiological feature of the lipid and lipoprotein abnormalities in dyslipidemia.

The primary objective of this study is to investigate VLDL-TG kinetics and hepatic insulin sensitivity in age-matched obese and lean, healthy men in the postabsorptive state and during acute hyperinsulinemia using VLDL-TG and glucose tracers.

Detailed Description

Extensive description not included.

Study Timeline

• Study Start: 2010-03
• Study First Submitted: 2010-08-24
• Primary Completion: 2010-09
• Study Completion: 2010-09
• Study First Submitted QC: 2010-09-17
• Study First Posted: 2010-09-20
• Status Verified: 2011-06
• Last Update Submitted: 2011-06-16
• Last Update Posted: 2011-06-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 24

Inclusion Criteria

• Healthy
• BMI < 25 kg/m2 or > 30 kg/m2
• Informed consent

Exclusion Criteria

• Alcohol misuse
• Smoking
• Use of prescription drugs

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Glucose clamp	Glucose clamp	-

Primary Outcome Measures

Name	Time	Method
VLDL-TG kinetics	VLDL-TG kinetics are determined postabsorptively (250 minues) and during acute hyperinsulinemia (450 minutes)	VLDL-TG secretion rates(umol/min) and clearance rates (ml/min)are determined during 30 min steady state periods postabsorptively and using acute hyperinsulinemia using primed-constant infusion of ex vivo-labelled 14C-VLDL-TG tracer and traditional tracer dilution technique.

Secondary Outcome Measures

Name	Time	Method
Hepatic insulin sensitivity	Glucose kinetics are determined postabsorptively (250 minues) and during acute hyperinsulinemia (450 minutes)	Hepatic glucose production (mg/min) is determined during 30 min steady state periods postabsorptively and during acute hyperinsulinemia using primed constant infusion og 3H-glucose tracer and traditional tracer dilution technique.

Trial Locations

Locations (1)

Department of Endocrinology and Internal Medicine, Aarhus University Hospital; 🇩🇰 Aarhus, Denmark