Analysis of the Intestinal Flora Composition After Consumption of Plant-based Beverages
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Change in gut microbiome alpha diversity
研究概览
简要总结
The goal of this intervention study is to analyse the microbiota composition after the plant-based beverage consumption. The main questions are to evaluate if the plant-based beverage can have a beneficial effect on the gut microbiota. Participants will consume different plant-based beverages for two weeks, and microbiota will be analysed. Researchers will compare the microbiota composition before and after consumption.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •- 18-65 years of age. • must be able to complete the form digitally.
排除标准
- •Must not be diagnosed with gastrointestinal diseases, autoimmune diseases or have diseases or medications that cause immune deficiency, such as MS, type 1 diabetes, cancer or HIV
- •must not take antibiotics during the study period
- •must not have a milk protein allergy
结局指标
主要结局
Change in gut microbiome alpha diversity
时间窗: up to 24 weeks
Gut microbiome alpha diversity will be assessed using 16S rRNA gene sequencing and quantified using alpha diversity indices (e.g., Shannon diversity index).
Change in gut microbiome beta diversity
时间窗: Upto 24 weeks
Gut microbiome beta diversity will be assessed using 16S rRNA gene sequencing by comparing community composition between samples using beta diversity distance metrics (e.g., Bray-Curtis dissimilarity or UniFrac distances).
次要结局
- Change in the relative abundance of gut bacterial taxa(Baseline to Week 24)
研究者
Åsa Håkansson
Associate Professor
Lund University