The Effect of Curcumin Supplementation on Anthropometric Indices, Insulin Resistance and Oxidative Stress in Patients With Type 2 Diabetes
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 44
- Locations
- 2
- Primary Endpoint
- Insulin
Study Overview
Brief Summary
Diabetes mellitus is the most common endocrine disorder, causes many complications such as micro- and macro-vascular diseases. Various kinds of antidiabetic drugs have been developed, but most of them have side effects. Recently, the use of natural plant products has gained more attention among scientists in order to prevent diabetic vascular complications. Curcumin is a natural yellow product derived from the turmeric rhizome which has shown to be non-toxic and exhibits various bio¬logical activities such as anti-oxidant, anti-inflammatory, anti-carcinogenic, and anti-diabetic effects. Curcumin is effective in reducing glycemic index and hyperlipidemia in rodent models and is relatively inexpensive and safe. Most of the studies conducted on animal model, and just a few of them are on human model. The present study was planned to evaluate the effects of curcumin supplementation The effect of curcumin supplementation on anthropometric indices, insulin resistance and oxidative stress in patients with type 2 diabetes
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Treatment
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 40 Years to 65 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •insulin Inclusion Criteria:
- •a) Tendency to participate b) Age range of 40-65 c) Suffering from diabetes type 2 ( between 1 to 10 yeares) d) BMI 18/5-30 e) Patients with diabetes who administer oral hypoglycemic agents and do not use
Exclusion Criteria
- •a) patients with liver diseases b) patients with kidney diseases c) patients with inflammatory diseases d) patients with liver diseases e) Administering herbal agents f) Administering multivitamins and minerals in past 3 months
Arms & Interventions
control
placebo
Intervention: Placebo (Dietary Supplement)
intervention
500 mg curcumin capsule
Intervention: Curcumin (Dietary Supplement)
Outcomes
Primary Outcomes
Insulin
Time Frame: 10 week
HbA1c
Time Frame: 10 week
fasting blood sugar
Time Frame: 10 weeks
Homeostatic Model Assessment of Insulin Resistance
Time Frame: 10 week
Change in pancreatic B-cell function
Time Frame: 10 week
Secondary Outcomes
- total capacity antioxidant(10 weeks)
- Malondialdehyde(10 week)
- Body mass index(10 week)
- Waist circumference(10 week)
Investigators
Dr Azita Hekmatdoost
Principal Investigator
National Nutrition and Food Technology Institute