High Versus Moderate Intensity Endurance Exercise Training in Treating Diastolic Heart Failure
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Heart Failure, Diastolic
- Sponsor
- Norwegian University of Science and Technology
- Locations
- 1
- Primary Endpoint
- Change in aerobic capacity measured as oxygen consumption
- Status
- Withdrawn
- Last Updated
- 10 years ago
Overview
Brief Summary
The purpose of this study is to determine whether endurance exercise of either high or moderate intensity can reverse structural and functional changes of the heart in patients with diastolic heart failure, and to investigate which type of exercise is best in terms of aerobe capacity and quality of life.
The investigators expect that high intensity endurance exercise is superior to moderate intensity endurance exercise.
Detailed Description
This study is a prospective randomized controlled intervention study comparing two active arms. Eligible patients are being sampled consecutively by cardiologists, and randomized to either high or moderate intensity endurance exercise. Endpoints are measured at baseline, 4 weeks and 7 months. The intervention is considered safe, and the study has been approved by the Regional Ethics Committee (REK-midt). This project has been financially supported by the Norwegian ExtraFoundation for Health and Rehabilitation through EXTRA funds.
Investigators
Eligibility Criteria
Inclusion Criteria
- •Sedentary lifestyle
- •Normal systolic function left ventricular ejection fraction (LVEF) \< 50%
- •New York Heart Association (NYHA) class II or III
- •Diastolic dysfunction (E/é \< 15 or E/é 8-15 and N-terminal proBNP \> 220pg/ml)
- •Medically stable the last 4 weeks
- •Written informed consent
Exclusion Criteria
- •Other causes of dyspnea than diastolic heart failure
- •Personal preferences or characteristics prohibiting the person from attending inpatient cardiac rehabilitation
- •Not able to perform physical exercise
Outcomes
Primary Outcomes
Change in aerobic capacity measured as oxygen consumption
Time Frame: Baseline and 7 months
Cardiopulmonary exercise test
Secondary Outcomes
- Changes in everyday activity level(Baseline to 7 months)
- Change in diastolic filling pressure measured as E/é(Baseline to 7 months)
- Arterial function measured as blood-vessel elasticity(Baseline to 7 months)
- Cardiac function measured as volume, size, efficacy(Baseline to 7 months)
- Quality of life(Baseline to 7 months)
- Feasibility, measured as attrition rate and compliance with exercise(Baseline to 7 months)
- Blood-risk profile, measured as changes in cholesterol, hemoglobin, N terminal-proBNP(Baseline to 7 months)