Clomiphene citrate plus Letrozole versus Clomiphene citrate alone for ovulation induction in infertile women with ovulatory dysfunction: a randomized controlled trial
- Conditions
- ovulation rateserum progesterone more than 3 ng/ml
- Registration Number
- TCTR20201108004
- Lead Sponsor
- Faculty of medicine, Siriraj Hospital
- Brief Summary
There was no significant difference between combination CC plus letrozole and CC alone relative to their ability to induce ovulation in infertile women with chronic anovulation. Further study is needed to compare the cumulative ovulatory rate and dose-defining efficacy of these ovulation induction regimens.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Female
- Target Recruitment
- 95
1. Women age between 18 and 40 years old
2. Infertile
3. Chronic anovulation (cycle length more than 35 days or diagnosed with PCOS)
4. Thai
1. Pregnancy
2. Received letrozole or clomiphene citrate within 3 month prior
3. Other causes of infertile, e.g. thyrotoxicosis, hyperprolactinemia
4. Uncontrolled underlying disease such as uncontrolled diabetes mellitus, uncontrolled hypertension, CA cervix
5. Allergic or contraindication to letrozole or clomiphene citrate
6. Husband has total motile sperm count less than 10 million
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method ovulation rate day 21 or 22 of cycle in patients with negative urinary LH test or 7 days after positive urinary LH serum progesterone in ng/ml
- Secondary Outcome Measures
Name Time Method side effect of medication after complete medication course inquiry questionnaires,Conception rate seven days after positive serum progesterone or day 35 of cycle if negative serum progesterone Urine pregnancy test,Clinical pregnancy 7 weeks after LMP Fetal heart beat,number of Dominant follicle day 12-14 of cycle Transvaginal ultrasound