difference between high intensity interval and moderate intensity continous intradialytic exercise on muscle quality index in hemodialysis patient

Phase 1

• Conditions: Musculoskeletal Diseases; Kidney Disease

• Registration Number: PACTR202302873028626
• Lead Sponsor: hadeer saber mansour

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-12-21
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Other
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

All patients will be included if they meet the following criteria:
1.Age between 45– 55 years.
2.Male sex included.
3.Patients with grade 5 chronic renal failure on hemodialysis.
4.Patients are on hemodialysis for 1-3 years.
5.Body mass index (BMI) range from 25-34.9 Kg/m2.
6.They will be medically and psychologically stable.
7.Receiving their physician-prescribed pharmacotherapy regularly.
8.Agree to participate by signing an informed consent form.

Exclusion Criteria

1.Inability to comprehend and follow instructions as in dementia or speech problems such as dysphasia.
2.Patients with unstable angina, uncontrolled cardiac arrhythmia, decompensated heart failure, persistent systolic blood pressure (BP) greater than 200 mmHg, persistent diastolic BP greater than 120 mmHg, acute pericarditis or myocarditis.
3.Acute systemic infection.
4.Presence of malignant disease.
5.Patients with Diabetes Mellitus.
6.Patients with Lupus Nephritis.
7.Patients with chronic obstructive lung disease, restrictive lung disease or chronic chest infection.
8.Severe obesity (BMI > 35).
9.Chronic inflammatory orthopedic disorders and rheumatoid arthritis.
10.Patients with muscle injuries or neuromuscular disorders (muscular dystrophy, myasthenia gravis, myopathy, multiple sclerosis and peripheral neuropathy).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
- Muscle quality index: to measure muscle quality and function MQI (Watts) = ((Leg length×0.4) ×Bodymass×gravity×10) / Time taken for (sit to stand 5 times) <br> - Six minute walk test (6MWT) to assess physical functional capacity <br> - QOL by using the questionnaire Medical Outcomes Study 36 (SF36)

Secondary Outcome Measures

Name	Time	Method
kidney function urea, creatinine, BUN , creatine phosphokinase total and CPK-MB