pright magnetic resonance imaging in COPD and diaphragm disease

niversity of Nottingham0 个研究点目标入组 31 人开始时间: 2018年5月23日最近更新: 2021年5月24日

适应症

试验速览

•Healthy volunteers and patients with diaphragm weakness (due to neuromuscular disease, e.g. motor neuron disease, and non-neuromuscular disease e.g. trauma) and patient with COPD with hyperinflation
•General inclusion criteria:
•1. Adult - male or female, aged 18 to 90 years old
•2. Capacity to give informed consent
•3. Able to hold their breath for 10 seconds
•4. Able to understand the requirements of the study and to cooperate with the study procedures
•Cohort-specific inclusion criteria:
•Healthy participants:
•1. No reported or diagnosed chronic respiratory disease
•COPD with hyperinflation:
•1. Evidence of airflow obstruction on spirometry – FEV1/FVC < 0.7 and FEV1 <80%
•2. Diagnosis of hyperinflation based on imaging or lung function measures
•Diaphragm weakness due to non-neuromuscular disease:
•1. Established diagnosis of diaphragm weakness due to non-neuromuscular disease, e.g. viral illness, trauma
•Diaphragm weakness due to neuromuscular disease:
•1. Established diagnosis of diaphragm weakness due to neuromuscular disease

•1. Unsuitable for MRI scanning (e.g. have metal implants or pacemaker or contraindicated following questionnaire)
•2. Deemed unlikely to comply with instructions during imaging
•3. Deemed not fit enough to tolerate procedure
•4. Deemed unsuitable by clinical investigator for other reasons
•5. History of lung volume reduction procedure

发起方

niversity of Nottingham