MIBG scintigraphy in patients with inherited monogenic electric heart diseases
- Conditions
- heart rhythm disordersventricular fibrillation10007521
- Registration Number
- NL-OMON31577
- Lead Sponsor
- Academisch Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 150
Inclusion Criteria
mutations carriers of the following diseases:
Long QT syndrome
Brugada syndrome
CPVT
Exclusion Criteria
pregnancy
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Differences between symptomatic and asymptomatic patients within a group with<br /><br>regards to the proportion of patients with abnormal MIBG scintigram.</p><br>
- Secondary Outcome Measures
Name Time Method <p>not applicable</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
How does MIBG scintigraphy evaluate sympathetic nerve activity in inherited monogenic arrhythmias like CPVT or Brugada syndrome?
What is the diagnostic accuracy of MIBG scintigraphy compared to standard ECG or Holter monitoring for predicting arrhythmic events in monogenic heart diseases?
Which genetic biomarkers (e.g., SCN5A, KCNQ1 mutations) correlate with MIBG uptake patterns in patients with inherited electric heart disorders?
What are the radiation exposure risks and management protocols for MIBG scintigraphy in pediatric and adult populations with monogenic arrhythmias?
How do MIBG imaging findings influence treatment strategies with beta-blockers or implantable cardioverter-defibrillators in inherited cardiac channelopathies?