The effect of oral L-arginine consumption on uterine artery resistance in women with recurrent implant failure

Phase 3

Recruiting

Conditions: infertility.
Female infertility, unspecified
N97.9

Registration Number: IRCT20220317054318N1

Lead Sponsor: Hamedan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Recruiting

Sex: Female

Target Recruitment: 72

Inclusion Criteria

Infertile women aged 18-41 years
Infertile IVF candidate women with a history of failure twice
Women with endometrium suitable for embryo transfer
Women with good quality embryos for transfer
Women who have passed 2 months or more since the last ICSI test and transfer.
Women who have the opportunity to attend the follow-up according to the plan and have informed consent
Women with a normal size and shape of the uterus that has been confirmed by ultrasound or hysteroscopy

Exclusion Criteria

Patients who use nitrite or organic nitrate at the same time
Women with chronic diseases such as: severe liver, kidney, or cardiovascular failure, patients with a history of stroke or myocardial infarction
Women smokers
Women with stage 3 and 4 endometriosis
Women with a known etiology of implant failure such as anatomical disorders (diagnosed by hysterosalpingography), hormonal disorders, immunological disorders, trophoblasts, antiphospholipid antibodies, mutation in factor V, pro-thrombin, crew disorders Musomes are excluded from the study
Patients with side effects of L-arginine
Canceling the treatment cycle for any reason
Unwillingness of the person to continue participating in the study

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
terine vascular resistance. Timepoint: At the beginning of the intervention and after taking L-arginine. Method of measurement: Color Doppler ultrasound.

Secondary Outcome Measures