Hemodynamic effects of simultaneous infusion of Milrinone and Terlipressin in pediatric patients with pulmonary hypertension undergoing on pump cardiac surgery

Not Applicable

Recruiting

• Conditions: Circulatory System; Surgery; Paediatrics; Cardiology; Anaesthesia

• Registration Number: PACTR202005520371433
• Lead Sponsor: Mansoura university children hospital

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2020-05-07
• Last Update Posted: 29 May 2023

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 75

Inclusion Criteria

The study will be conducted on 75 patients of either sex with the following inclusion criteria
1.Age 1–4 years.
2.Elective corrective open heart surgery using cardiopulmonary bypass (CPB).
3.Congenital cardiac anomalies associated with pulmonary hypertension (PAH-CHD) with pulmonary artery pressure (PAP) more than 40 mmhg.

Exclusion Criteria

1.Patients with previous open heart surgery.
2.Neurological, renal or hepatic disease.
3.Decompensated heart failure.
4.Eisenmenger syndrome or right to left shunts.
5.Presence of preoperative coagulation disorders.
6.Contraindication to use TEE.
7.Hypersensitivity of any of the studied drugs.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
assess systolic pulmonary artery pressure in the intra-operative and 24 hours post-operative periods.

Secondary Outcome Measures

Name	Time	Method
the patients' heart rate, blood pressure, TEE data, arterial blood gases tensions, time of extubation and ICU and hospital length of stays.