Management of Mixed-Phenotype Acute Leukemia in the East of France
试验速览
- 阶段
- 不适用
- 发起方
- 入组人数
- 70
- 主要终点
- Medullar MPO positivity percentage at diagnosis for each patient
研究概览
简要总结
Clinical presentation and management of Mixed-Phenotype Acute leukemia (MPAL) is heterogeneous. This descriptive observationnal study aims to review MPAL cases in the East of France based on a 10-year multicentre retrospective collection.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Only
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adult patients over 18 years of age
- •Diagnosis of biphenotypic acute leukemia or mixed-phenotype acute leukemia between 2008 and 2018
排除标准
- 未提供
结局指标
主要结局
Medullar MPO positivity percentage at diagnosis for each patient
时间窗: At inclusion (Day 0)
If performed on the bone marrow sample used to confirm the diagnosis
Genetic characteristics on molecular biology analysis at diagnosis for each patient
时间窗: At inclusion (D0)
Presence or not of molecular biology abnormalities generally sought in the diagnosis of acute leukemias
Age of the patients when diagnosed with MPAL
时间窗: At inclusion (Day 0)
Age in years
Sex of the patients when diagnosed with MPAL
时间窗: At inclusion (Day 0)
Male or female
Percentage of medullar blasts for each patient at diagnosis of MPAL
时间窗: At inclusion (Day 0)
On the first bone marrow sample analyzed
Classification of biphenotypic acute leukemia (BAL) according to the EGIL 1998 criterias at diagnosis
时间窗: At inclusion (Day 0)
BAL or not
Cytologic characteristics: type of B lymphoid markers at diagnosis for each patient
时间窗: At inclusion (Day 0)
Presence or not of B lymphoid markers generally sought in the diagnosis of acute leukaemias
MPAL rate in the each hematology unit
时间窗: 10 years (01/01/2008-01/01/2018)
Rate of MPAL out of the total number of patients diagnosed with acute leukemia in each hematology unit
City of the hematology unit in charge of each patient for the treatment of MPAL
时间窗: At inclusion (Day 0)
Nancy, Metz-Thionville, Reims, Strasbourg, Mulhouse, Dijon or Besançon
Date of MPAL diagnosis for each patient
时间窗: At inclusion (Day 0)
Percentage of blood blasts for each patient at diagnosis of MPAL
时间窗: At inclusion (D0)
On the first blood sample analyzed
Classification of MPAL according to the WHO 2008 criterias at diagnosis
时间窗: At inclusion (Day 0)
MPAL or not
Type of treatments and dates of the first day of every treatment line for each patient
时间窗: 10 years (01/01/2008-01/01/2018)
Myeloid or lymphoid chemotherapy regimen
Type of MPAL for each patient
时间窗: At inclusion (Day 0)
De novo MPAL or secondary to myelodysplasia MPAL
Genetic characteristics on the caryotype at diagnosis for each patient
时间窗: At inclusion (Day 0)
Presence or not of caryotypic abnormalities generally sought in the diagnosis of acute leukemias
Medullar response for every treatments line for each patient
时间窗: 10 years (01/01/2008-01/01/2018)
Complete cytological and molecular response or treatment failure
Treatment including allogenic hematopoietic stem cells transplant (HSCT) (yes or no) with type of conditionning regimen for each patient
时间窗: 10 years (01/01/2008-01/01/2018)
High-dose, reduced-intensity or nonmyeloablative conditioning regimens with or without total body irradiation
Cytologic characteristics: type of myeloid markers at diagnosis for each patient
时间窗: At inclusion (Day 0)
Presence or not of myeloid markers generally sought in the diagnosis of acute leukaemias
Cytologic characteristics: type of T lymphoid markers
时间窗: At inclusion (D0)
Presence or not of T lymphoid markers generally sought in the diagnosis of acute leukemias
HSCT complicated with acute and/or chronic graft-versus-host disease with severity grade and treatments for each patient
时间窗: 10 years (01/01/2008-01/01/2018)
Diagnosis of GVHD according to Filipovich criterias (BMT 2005); Severity grade according to Seattle criterias; Type of treatments: steroids, other immunosuppressive agents, extracorporeal photopheresis
次要结局
- Date of every relapse for each patient(10 years (01/01/2008-01/01/2018))
- Cause of death(10 years (01/01/2008-01/01/2018))
- Date of death if occured(10 years (01/01/2008-01/01/2018))