Acute effect of the oral contraceptive pill on glucose regulatio

Not Applicable

Completed

• Conditions: Type 2 diabetes; Obesity; Metabolic and Endocrine - Diabetes; Diet and Nutrition - Obesity

• Registration Number: ACTRN12618000858291
• Lead Sponsor: Dr Jennifer Miles-Chan

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2018-05-22
• Study Completion: 2020-12-03
• Last Update Posted: 26 October 2021

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 21

Inclusion Criteria

Provision of informed consent
Female 
Aged 18­-40 years
BMI 18.5 - 24.9 kg/m2
Self­ reported healthy
Combined monophasic oral contraceptive pill use for >3 months
Self-reported with regular menses.

Exclusion Criteria

Pregnancy or breastfeeding
History of chronic disease
Use of any medication other than the oral contraceptive pill during the last 3 months
Vegetarian
Claustrophobia

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Plasma profile of metabolic biomarkers (e.g, glucose, insulin, C-peptide) as assessed by Roche/Hitachi Cobas auto-analyser and multiplex assays. [Baseline (Fasted) - T-15 minutes<br>Post-prandial - T15 minutes, T30 minutes, T60 minutes, T90 minutes, T120 minutes, T180 minutes, T240 minutes<br><br>There is no one primary timepoint as we will look at the area under the curve (AUC).];Metabolic rate (energy expenditure) measured by indirect calorimetery using an open-circuit ventilated hood system (Quark, Cosmed srl, Rome, Italy). <br><br>[Baseline (Fasted) - T-45 to T0 minutes<br>Post-prandial - continuous measurement from T15 minutes to T245 minutes<br><br>There is no one primary timepoint as we will look at the area under the curve (AUC).]