Effect of Stevia Extract on Postprandial Glucose Response and Satiety in Overweight and Obese Adults: A Three-arm Crossover Trial.
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 试验地点
- 2
- 主要终点
- Postprandial glucose levels
研究概览
简要总结
This study aims to assess the effect of stevia extract on postprandial glucose and insulin levels in overweight and obese adults when compared to sugar and water.
详细描述
The study is a three-arm crossover trial involving participants attending the Lab on 3 different occasions (separated by 3-5 day washout period), where they will be administered water, sugar solution (65g), water and stevia extract (5g) solution. The solution will be followed by a consumption of a fixed meal (after 30 minutes). Breakfast will be standardised. Capillary blood glucose will be collected every 30 min until 2 hours post meal. Venous blood samples will be collected before the intake of the solution and at 2 hours after meal intake.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Single (Participant)
盲法说明
Single (participant)
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age 18-65 years
- •BMI 27-40 Kg/m2
- •Males and females
排除标准
- •Pregnant or breastfeeding women
- •Patients with chronic disease (diabetes, CVD etc...).
结局指标
主要结局
Postprandial glucose levels
时间窗: Capillary blood glucose will be measured two hours after the administration of a fixed meal.
Change in glucose levels two hours after the administration of a fixed meal
次要结局
- Postprandial insulin levels(Postprandial insulin levels will be measured two hours of the administration of a fixed meal)
- Subjective feelings of satiety(VAS will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch.)
- Area under the curve (AUC) for glucose(Capillary blood glucose levels will be collected 6 times on each visit before the intake of the solution until 2 hours post lunch)
研究者
Grace Farhat
Dr
Liverpool Hope University