Mechanism-based Choice of Therapy for Pain: Can Successful Prevention of Migraine be Coupled to a Psychophysical Pain Modulation Profile?

Not Applicable

Completed

• Conditions: Migraine
• Interventions: Drug: Amitriptyline; Drug: Topiramate

• Registration Number: NCT01161017
• Lead Sponsor: Rambam Health Care Campus

Brief Summary

Mechanism-based choice of therapy for pain:

Can successful prevention of migraine be coupled to a psychophysical pain modulation profile?

Detailed Description

Not available

Study Timeline

• Study Start: 2008-07
• Study First Submitted: 2010-07-10
• Study First Submitted QC: 2010-07-12
• Study First Posted: 2010-07-13
• Primary Completion: 2014-05
• Study Completion: 2014-05
• Status Verified: 2017-10
• Last Update Submitted: 2017-10-10
• Last Update Posted: 2017-10-11

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 67

Inclusion Criteria

• female and male migraine patients with a number of month attacks ≥ 4,
• age 18-75,
• without any other chronic pain.

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Exclusion Criteria

• any migraine preventive treatment for last 6 month & psychiatric,
• language or cognitive dysfunction precluding use of psychophysics.

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
1 Amitriptyline.	Amitriptyline	Amitriptyline
2 Topiramate	Topiramate	Topiramate

Primary Outcome Measures

Name	Time	Method
Therapeutic response to the analgesic drugs	2 months

Trial Locations

Locations (1)

Rambam Medical Center; 🇮🇱 Haifa, Israel