High Protein Diet , CRP and CVD Risk Factors
试验速览
- 阶段
- 3 期
- 状态
- 已完成
- 入组人数
- 63
- 主要终点
- the amount of weight reduction in two dietary groups
研究概览
简要总结
The investigators aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.
详细描述
Background: Studies regarding the effects of high protein (HP) diet on cardiovascular (CVD) risk factors have reported contradictory results.
Objective
In present study, we aimed to determine the effects of HP diet on CVD risk factors and hs-CRP among overweight and obese women.
Design: In this randomized controlled trial, we recruited 60 overweight and obese women, aged 20-65 years into HP or control energy restricted diets for three months (protein, carbohydrate, fat: 25%, 45%, 30% vs. 15%, 55%, 30%, respectively). Total protein amount, divided to animal and plant sources in 50%-50% and animal sources distributed (half/half) between meats and dairy products. Fasting blood samples, hs-CRP, lipid profile, systolic and diastolic blood pressure and anthropometric measurements were measured based on the standard guidelines.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Health Services Research
- 盲法
- Single (Participant)
入排标准
- 年龄范围
- 20 Years 至 65 Years（Adult, Older Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •women aged between 20-65 years
- •BMI > 25 kg/m2
- •were no smoker
- •no history of renal, liver, metabolic diseases or type 1 or 2 diabetes
排除标准
- •had gastrointestinal, respiratory, cardiovascular, metabolic, liver and renal -diseases
- •had macroalbuminuria
- •were pregnancy or lactating
结局指标
主要结局
the amount of weight reduction in two dietary groups
时间窗: 3 months
weight reduction (kg)
次要结局
- LDL-C (mg/dl(3 months)
- HDL-C (mg/dl)(3 months)
- total cholesterol (mg/dl)(3 months)
- fasting blood glucose(mg/dl)(3 months)
- blood pressure (mmHg)(3 months)
- C-reactive protein (mc/dl)(3 months)
研究者
Leila Azadbakht
Isfahan University of Medical Sciences,
Isfahan University of Medical Sciences