Preference of Genetic Polymorphism and Pharmacokinetics

Completed

• Conditions: HIV

• Registration Number: NCT01658371
• Lead Sponsor: Chinese University of Hong Kong

Brief Summary

Genetic polymorphism affects plasma concentration of antiretroviral therapy in HIV patients. The investigators investigate the prevalence of genetic polymorphism affecting efavirenz metabolism and the corresponding pharmacokinetics of different genotypes.

Detailed Description

Eligible patients are invited to donate blood samples for pharmacokinetic study and genotype analysis

Study Timeline

• Study Start: 2008-05
• Primary Completion: 2009-12
• Study Completion: 2010-06
• Study First Submitted: 2012-02-27
• Status Verified: 2012-08
• Study First Submitted QC: 2012-08-02
• Last Update Submitted: 2012-08-02
• Study First Posted: 2012-08-07
• Last Update Posted: 2012-08-07

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 100

Inclusion Criteria

• Southern Chinese HIV patients on efavirenz

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Exclusion Criteria

• Refuse to sign consent, HIV patients not on efavirenz

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
pharmacokinetics	24 hour	This includes plasma concentration of drugs in relation to time, in different genotypes

Secondary Outcome Measures

Name	Time	Method
genotypes frequency	1 year

Trial Locations

Locations (1)

The Chinese University of Hong Kong; 🇨🇳 Hong Kong, Hong Kong, China