The effect of a one off bout of cycling exercise on the release of small proteins into the circulation in haemodialysis patients

Not Applicable

• Conditions: Cardiovascular risk in haemodialysis patients; Urological and Genital Diseases

• Registration Number: ISRCTN17464516
• Lead Sponsor: niversity of Leicester

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-02-16
• Last Update Posted: 27 February 2023
• Study Completion: 2025-03-14

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

Patients undergoing maintenance haemodialysis for more than 3 months

Exclusion Criteria

1. Age <18 years
2. Pregnancy
3. Inability to give informed consent
4. Physical disability that prevents exercise
5. Blood borne diseases

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Characterisation of exosome release following 30 mins of acute cycling exercise in patients with chronic kidney disease, measured by Next Generation Sequencing (raw counts) at baseline, immediately post exercise.

Secondary Outcome Measures

Name	Time	Method
<br> 1. Define the time course of exosome release following acute cycling exercise, measured using the Nanosight (particle numbers) at baseline, immediately post, 10, 30, 60 and 90 minutes post exercise.<br> 2. Characterise the microRNA profiles within circulating exosomes, measured using PCR (cT values) in samples taken at 10, 30, 60 and 90 minutes post exercise.<br> 3. Relate microRNA profiles to clinical data regarding clinical remodelling determined using regression modelling (r2 values) using values immediately post exercise and their baseline characteristics.<br>