Impact of Prophylactic Antibiotics on Bloodstream Infections After Liberation From Extracorporeal Membrane Oxygenation
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 入组人数
- 42
- 试验地点
- 1
- 主要终点
- Growth of pathogens in blood culture
研究概览
简要总结
The goal of this prospective interventional study is to evaluate the impact of antibiotic prophylaxis on bloodstream infections after liberation of extracorporeal membrane oxygenation therapy. The main questions aims to answer are:
• does application of vancomycine prior to ECMO liberation have an impact of bloodstream infections?
Participants will get 1 dose of vancomycine I.V. (15-20 mg per kgKG) prior to liberation of ECMO.
Researchers will compare this interventional group to a group without antibiotic prophylaxis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •adult patients older than 18 years
- •ECMO-Therapy
排除标准
- •patients younger than 18 years
- •fever >38,5°C
- •pregnancy
- •antibiotic treatment with Vancomycine, Linezolid, Daptomycin or Tygacil on the day of liberation
- •prior adverse events after application of Vancomycine
研究组 & 干预措施
Intervention: Prophylactic antibiotic treatment
Application of 15-20 mg per kgKG Vancomycine I.V. prior to ECMO liberation
干预措施: Vancomycine (Drug)
结局指标
主要结局
Growth of pathogens in blood culture
时间窗: taken directly before removal of extracorporeal membrane oxygenation therapy
Detection of pathogens / blood stream infection
次要结局
- laboratory parameters(72 hours after liberation of extracorporeal membrane oxygenation therapy)
- Growth of pathogens on cannula tip(on the day of liberation, cannula tip will be send to institute of microbiology directly after liberation from ECMO)
研究者
Philipp Lepper
Deputy Director
Universität des Saarlandes