Evaluation of the effectiveness of titanium-prepared platelet rich fibrin (T-PRF) and demineralized freeze-dried bone allograft (DFDBA) in socket preservation followed by implant placement using two stage approach.â€
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 12
- 试验地点
- 1
- 主要终点
- 3. To evaluate success rate of delayed implant placement in ridge preservation / socket preservation.
研究概览
简要总结
ABSTRACT
Background: Implant dentistry has evolved over time with variousnovel protocols. The focus of the implant therapy is nowshifting to a stable restoration rather than mere osseointegration. Placement of dental implants has become anindispensable part of mainstream dentistry, offering an improved quality oflife to patients. The primary indicator for the repair or preservation ofosseous structures following disease or trauma is the rehabilitation ofedentulous ridges to allow the installation of endosseous implants. One of thephysiological changes that occurs after tooth extraction is alveolar ridgeresorption. The first yearafter tooth extraction sees major dimensional shifts in the extraction socket,with two-thirds of the bone loss occurring during the first three months. A variety of bone graft materials and platelet concentrates whichare abundant in growth factors have been incorporated that provides the addedeffect of combination for early and better healing.
Objectives: Evaluation of effectiveness of “Titanium Prepared Platelet RichFibrinâ€(T-PRF) and “Demineralized Freeze-Dried Bone Graftâ€(DFDBA) in socketpreservation and simultaneous evaluation of implant stability three months after implant placement using twostage protocol.
Methodology: Present study will be performed over one year period. Twelvepatients, each having one tooth indicated for extraction in either of thearches will be selected. Atraumatic extraction will be done followed by socketpreservation using combination of T-PRF and DFDBA to promote early healingfollowed by placement of implant.
Expected results: We expect early and better results of bone formation in healingsockets after preservation using T-PRF and DFDBA, which will be advantageousfor implant placement. Better results in terms of bone volume, bone height,bone density and histomorphometry are expected.
Conclusion: Combination of T-PRF and DFDBA is expected ofcreating novel outcomes.
Keywords: T-PRF, Socket Preservation, Dental Implant, DFDBA.
研究设计
- 研究类型
- Interventional
- 分配方式
- Not Applicable
- 盲法
- Not Applicable
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Inclusion criterias: 1.Tooth indicated for extraction.
- •Reasons might be any one like, fracture of root, failure of endodontic treatment, resorption (internal and external), over-retained primary teeth, non-restorable carious lesions, residual roots.
- •2.Oral hygiene indicated with plaque score ≤ 25%.
- •3.Presence of opposing natural tooth.
- •4.Presence of adjacent teeth.
- •5.Thick gingival biotype.
- •6.Radiographic and clinical appearance of intact alveolar bony walls.
- •4 mm of bone radiographically at root apex 8.D-1, D-2 or D-3 bone quality.
排除标准
- •Exclusion criterias: 1.Patients with impaired systemic health that would interfere with the process involved with repair and healing of bones e.g. (Diabetes mellitus, Osteoporosis, Blood disorders, and Titanium allergy).
- •2.Significant differences in maxilla-mandibular space.
- •3.Presence of para functional habits such as bruxism or clenching.
- •4.Presence of proclined teeth, teeth with interdental spacing, rotated or mal-aligned anterior teeth.
- •5.History of alcoholism, excessive smoking or drug abuse.
- •6.D-4 bone quality.
- •7.Width of keratinized gingiva less than 2mm at implant site.
- •8.Debilitating tempro-mandibular joint pathosis.
- •9.Untreated dental diseases.
- •10.Pregnant and lactating mothers.
结局指标
主要结局
3. To evaluate success rate of delayed implant placement in ridge preservation / socket preservation.
时间窗: To be evaluated after 3 months of ridge preservation and then after 3 months of implant placement
2. To evaluate vertical and horizontal crestal bone changes around post extraction implant placement.
时间窗: To be evaluated after 3 months of ridge preservation and then after 3 months of implant placement
1. To evaluate bucco-lingual changes of sockets before and after ridge preservation.
时间窗: To be evaluated after 3 months of ridge preservation and then after 3 months of implant placement
次要结局
未报告次要终点