Effect of Dissolving Xylitol Chewable Tablets Versus Xylitol Chewing Gum on Salivary pH and Bacterial Count in Geriatric Bedridden Patients : Randomized Clinical Trial
Trial Snapshot
- Phase
- Early Phase 1
- Sponsor
- Cairo University
- Enrollment
- 98
- Locations
- 1
- Primary Endpoint
- Salivary bacterial count
Study Overview
Brief Summary
This study will be conducted to evaluate the effectiveness of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients in increasing salivary pH and decreasing bacterial count in both saliva and interdental plaque.
Detailed Description
This study will be conducted to evaluate the value of using dissolving Xylitol chewable tablets versus xylitol chewing gum with bedridden geriatric patients ,as an alternative to tooth brushing and mouth rinsing, in increasing salivary pH and decreasing bacterial count in both saliva and interdental plaque.plaque and salivary sampling will be taken in certain time ,at baseline T0, then after 5minutes T1, then at 15 days T3. Salivary pH will be measured by using pH meter and streptococcus mutans bacterial count will be calculated through culture in mitis salivarius bacitracin
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Parallel
- Primary Purpose
- Prevention
- Masking
- Double (Investigator, Outcomes Assessor)
Masking Description
The operator will be blinded to material and assessors will be blinded to the material assignment.
Eligibility Criteria
- Ages
- 65 Years to — (Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age range above 65 years old
- •Bedridden patients
- •Males or females
- •Concious patients
- •Co-operative patients approving to participate in the trial.
- •Subjects who signed informed consent
Exclusion Criteria
- •Individuals had taken antibiotics during the last four weeks or anticipated doing so during the study
- •Subjects who wore removable prosthesis
- •Patients with systemic diseases that have any oral manifestations
- •History of Smoking
- •Allergy to any of chewing gum or tablets ingredients
- •Evidence of tempromandibular joint disorders
- •Presence of intraoral infections
- •Currently using any mouth rinse
Arms & Interventions
Dissolving xylitol chewable tablets
Listerine ready tabs 3 times/day
Intervention: Listerine ready tabs (Drug)
Xylitol chewing gum
Trident original 3 times/day
Intervention: Listerine ready tabs (Drug)
Outcomes
Primary Outcomes
Salivary bacterial count
Time Frame: 15 days
Streptococcus mutans count in saliva
Secondary Outcomes
- Interdental plaque Bacterial count(15 days)
Investigators
Manar abd elmageed ahmed
Manar abd El mageed ahmed
Cairo University