Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect (In-vivo and In-vitro Study)
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Dental Caries
- Sponsor
- Università degli Studi di Sassari
- Enrollment
- 32
- Locations
- 1
- Primary Endpoint
- Change of Salivary concentration of Xylitol
- Status
- Completed
- Last Updated
- 6 years ago
Overview
Brief Summary
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol. The study had a cross-over design: the first half of the sample used the chewing-gum with Xylitol as the only sweeteners (64.5% of chewing-gum weight) and the other half use the chewing-gum with Xylitol among the sweeteners (22% of chewing-gum weight), after a 7-days wash-out period, the two sub-groups inverted the chewing gums. Subjects were instructed to consume the products as they normally would be consumed.
Detailed Description
x
Investigators
Guglielmo Campus
Professor of Public Health Dentistry
Università degli Studi di Sassari
Eligibility Criteria
Inclusion Criteria
- •good general health,
- •the absence of diseases that can alter the saliva secretion rate
- •a stimulated saliva flow at least of 1 ml/min.
Exclusion Criteria
- Not provided
Outcomes
Primary Outcomes
Change of Salivary concentration of Xylitol
Time Frame: 9 days
Xylitol concentration using spectrophotometer analysis was determined in saliva before, at 0.30, 1.00, 2.00, 5.00, 10.00 minutes using the chewing-gum, and after the gum discarded at 15.00, 20.00 and 25.00 minutes.