Arginine and Nitric Oxide (NO) Metabolism in Healthy Human Volunteers
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 33
- 主要终点
- whole body NO synthesis
研究概览
简要总结
Investigation of arginine and NO metabolism in healthy subjects is important as a reference for alterations in arginine-NO metabolism in patients. Moreover, this study will indicate the changes during aging and gender-related differences. Although data on arginine metabolism exist in literature, data are limited to young healthy male subjects. Since patients with suspected changes in arginine metabolism, e.g. sepsis and cancer patients are often elderly and also women, knowledge of arginine metabolism in these groups is needed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Written informed consent
- •Age 18-25 years (young); 50-70 years (middle aged/elderly)
排除标准
- •Diabetes mellitus type I
- •Livercirrhosis, pancreatitis, malignancies
- •Hypertension (diastolic blood pressure >95 mmHg or systolic blood pressure >160 mmHg)
- •History of gastrointestinal complaints
- •Recent involuntary weight loss (more than 10 % in 6 months or more than 5 % in one month)
- •Pregnancy (pregnancy test is done in female subjects)
- •Use of medication that can affect arginine metabolism (nitrovasodilators and corticosteroids)
- •Subjects with "high activity level"
研究组 & 干预措施
stable isotopes
stable isotope infusion for measurement of metabolism
干预措施: stable isotope infusion for measurement of metabolism (Other)
结局指标
主要结局
whole body NO synthesis
时间窗: 2 hours
postabsorptive nitric oxide synthesis measured by using stable isotope methodology
次要结局
- whole body protein metabolism(2 hours)
- whole body arginine metabolism(2 hours)
- blood parameters(2 hours)