Postconditioning in the Treatment of Acute ST-segment Elevation Myocardial Infarction
- Conditions
- ST-segment Myocardial Infarction
- Registration Number
- NCT00507156
- Lead Sponsor
- Rigshospitalet, Denmark
- Brief Summary
Standard treatment of patients with acute ST-segment elevation myocardial infarction consist of acute re-opening of the occluded coronary artery (primary PCI). Despite successful treatment of the epicardial vessel reperfusion is sometimes inadequate leading to large final infarct sizes. This phenomenon is known as the reperfusion injury. Several animal studies have indicated that graded re-opening of the artery may limit tissue damage. Generally this is referred to as mechanical postconditioning.
The study investigates the effect on final infarct size evaluated by magnetic resonance scan of postconditioning of ST-segment elevation myocardial infarctions. Mechanical postconditioning is performed by means of several balloon inflations in the injured vessel following its acute re-opening.
- Detailed Description
Please see above
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 200
- Patients more than 18 years
- STEMI < 12 hours
- TIMI 0-1 in infarct related artery
- Multivessel disease (stenoses in non-infarct related arteries >70%)
- Cardiogenic shock
- Left main occlusions
- Lesions that cannot be treated with stents
- Previous CABG
- Pregnancy
- Severe renal insufficiency
- Previous extensive Q-wave infarction
- LBBB
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Final infarct size evaluated by MR 3 month
- Secondary Outcome Measures
Name Time Method MACE (death, re-infarction, TLR) 1, 15 month Stent thrombosis 15 month
Related Research Topics
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Trial Locations
- Locations (1)
Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen
🇩🇰Copenhagen, Denmark
Cardiac Catherization Lab., Heart Center, Rigshospitalet, University of Copenhagen🇩🇰Copenhagen, Denmark