White Matter Hyperintensities in Migraine: A Multi-modal Imaging Project to Classify Disease Pathology
试验速览
- 阶段
- 不适用
- 状态
- 进行中（未招募）
- 发起方
- Mayo Clinic
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- WMH imaging disease parameters
研究概览
简要总结
The purpose of this research is to better understand brain white matter hyperintensities (WMH) in women with migraines
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 59 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 否
入选标准
- •Migraine (N=20):
- •Female only.
- •Ages 20-45 years.
- •Presence of WMH on MRI.
排除标准
- •History of SVI and/or history of MS or other neurological disease other than migraine.
- •History of cancer or organ transplantation.
- •Contraindication to MRI.
- •Pregnancy.
- •History of abnormal brain MRI other than WMH.
- •Subjects not willing to comply with the study procedures will be removed from the study.
- •Inclusion Criteria - SVI disease (n=10):
- •Female only
- •Ages > 60 years.
- •Presence of WMH on MRI.
- •Exclusion Criteria:
- •History of migraine and/or history of MS or other neurological disease other than SVI.
- •History of cancer or organ transplantation.
- •History of abnormal brain MRI other than WMH.
- •Pregnancy.
- •History of abnormal brain MRI other than WMH.
- •Subjects not willing to comply with the study procedures will be removed from the study.
- •Inclusion Criteria - MS (n=10):
- •Female only.
- •Presence of WMH on MRI.
- •Exclusion Criteria:
- •History of migraine and/or history of SVI or other neurological disease other than MS.
- •History of cancer or organ transplantation.
- •History of abnormal brain MRI other than WMH.
- •Pregnancy.
- •History of abnormal brain MRI other than WMH.
- •Subjects not willing to comply with the study procedures will be removed from the study.
研究组 & 干预措施
Migraine cohort
Women with migraine and presence of white matter hyperintensities (WMH) on clinical magnetic resonance imaging (MRI) will have brain neuroimaging.
干预措施: Brain Neuroimaging (Diagnostic Test)
Multiple sclerosis (MS) cohort
Women diagnosed with MS and presence of white matter hyperintensities (WMH) on clinical magnetic resonance imaging (MRI) will have brain neuroimaging.
干预措施: Brain Neuroimaging (Diagnostic Test)
Small vessel ischemic (SVI) disease cohort
Women diagnosed with SVI disease and presence of white matter hyperintensities (WMH) on clinical magnetic resonance imaging (MRI) will have brain neuroimaging.
干预措施: Brain Neuroimaging (Diagnostic Test)
结局指标
主要结局
WMH imaging disease parameters
时间窗: 3 months
Radiological MRI assessment of WMH in migraine
次要结局
未报告次要终点
研究者
Catherine (Cat) Chong
Principal Investigator
Mayo Clinic