A randomized controlled trial using surgical gloves to prevent chemotherapy-induced peripheral neuropathy by paclitaxel in breast cancer patients (AIUR trial)

The Catholic University of Korea, Incheon St. Mary's Hospital0 个研究点目标入组 104 人开始时间: 待定最近更新: 2023年5月2日

试验速览

暂无简介。

•Age greater or equal to 19 years, under 70 years old
•-Stage II-III breast cancer
•-No distant metastasis
•-Patient scheduled to be receiving adjuvant or neoadjuvant paclitaxel for at least 12 weeks
•-Signed informed consent
•-Eastern Cooperative Oncology Group (ECOG) performance status = 2 (Karnofsky =60%)

•-Recurred breast cancer
•-Patients who have previously received treatment that could cause neuropathy; taxane or platinum-based chemotherapy, antitubulins, proteasome inhibitors
•-Known history of neuropathy
•-Chronic kidney disease
•-Raynaud’s phenomenon
•-Peripheral vascular disease; peripheral arterial ischemia
•-Cold intolerance
•-Allergy in natural rubber latex or surgical gloves
•-Patients who have dermatitis, wound, or musculoskeletal problems in hand at enrollment
•-Current use medications which may mitigate chemotherapy-induced peripheral neuropathy; duloxetine, gabapentin/pregabalin, BAK (topical amitriptyline, ketamine, ±baclofen), oral cannabinoids, tricyclic antidepressants, ganglioside-monosialic acid
•-Patients' condition that interferes with understanding and submitting the consent form

发起方

The Catholic University of Korea, Incheon St. Mary's Hospital