Cardiac computed tomography (CT) for the Assessment of chest Pain and Plaque: a randomised controlled trial

lster Hospital (UK)0 sites500 target enrollmentSeptember 7, 2010

Overview

No summary available.

Registry

who.int

Start Date

September 7, 2010

End Date

TBD

Last Updated

9 years ago

Study Type

Observational

Sex

All

Sponsor

lster Hospital (UK)

•1\. Patients over 40 referred to the Rapid Access Chest Pain Clinic (RACPC), Ulster Hospital, Northern Ireland for suspicion of angina
•2\. Patients must have the ability to hold breath

•1\. Less than 40 years of age
•2\. Significant renal dysfunction with an estimated Glomerular Filtration Rate (eGFR) less than 35\. As the contrast used in CCT and conventional angiography can cause contrast nephropathy these patients with will be excluded from the study
•3\. Recent history of alcohol, drug abuse, or other medical conditions that might compromise safety, successful completion of, or drug compliance during the study
•4\. Patients with a history of chronic inflammatory conditions, such as severe arthritis, lupus, or inflammatory bowel disease, as well as subjects taking immunosuppressant agents, such as cyclosporine, tacrolimus, azathioprine, or chronic oral glucocorticoids. Because High\-Sensitivity C\-Reactive Protein (hs\-CRP) will be measured, patients with other conditions that may cause a chronically elevated CRP will be excluded.
•5\. Unstable angina pectoris
•6\. Uncontrolled fast atrial fibrillation or other arrhythmias that may interfere with ECG\-gated triggering of CT
•7\. Patients with extreme tachycardia, greater than 110 bpm, despite rate controlling agents
•8\. Pregnancy
•9\. Morbid obesity (Body Mass Index \[BMI] \>35\)
•10\. Known contrast medium allergy