Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

Withdrawn

• Conditions: Covid19; Ventilation Perfusion Mismatch; Pulmonary Edema; Respiratory Distress Syndrome, Adult

• Registration Number: NCT04508933
• Lead Sponsor: Istanbul University - Cerrahpasa (IUC)

Brief Summary

Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2020-08-08
• Study First Submitted QC: 2020-08-10
• Study First Posted: 2020-08-11
• Study Start: 2020-09-01
• Primary Completion: 2020-09-30
• Study Completion: 2020-12-31
• Status Verified: 2021-10
• Last Update Submitted: 2021-10-21
• Last Update Posted: 2021-10-26

Recruitment & Eligibility

• Status: WITHDRAWN
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• ARDS defined by Berlin Criteria longer than 24 hours
• Undergoing mechanical ventilation
• Noradrenaline demand >0.1 mcg/kg/min

Exclusion Criteria

• Not meeting ARDS criteria
• Noninvasive mechanical ventilation
• ARDS resolved shorter than 24 hours
• Shock resolved

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Extravascular Lung Water Index	1 day	The amount of fluid accumulated in the lung measured by transpulmonary thermodilution (ml/kg)
Pulmonary vascular permeability index	1 day	Integrity of the alveolocapillary barrier measured by transpulmonary thermodilution

Trial Locations

Locations (1)

Istanbul University-Cerrahpaşa; 🇹🇷 Istanbul, Turkey