China Health Big Data

Recruiting

• Conditions: Liver Steatoses; Obesity; Osteoporosis

• Registration Number: NCT03699228
• Lead Sponsor: Beijing Jishuitan Hospital

Brief Summary

In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. The aim of this study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

Detailed Description

Low dose Chest CT scan is the standard for lung cancer in the health check center in China. Quantitative computed tomography (QCT) is utilizing the CT raw data to measure the bone mineral density (BMD), the visceral fat (VAT) and liver fat content in human, which can be widely used in the diagnosis of osteoporosis, the assessment of obesity and liver steatosis. In this nationwide multi center study the investigators combine the low dose chest CT scan data with QCT technology, to measure the BMD of spine, VAT and liver fat in the health check subjects. This study is to evaluate the performance of QCT in the health check field, and further to evaluate the prevalence of osteoporosis, obesity and liver steatosis in health check population across China.

Study Timeline

• Study Start: 2017-12-01
• Study First Submitted: 2018-10-05
• Study First Submitted QC: 2018-10-05
• Study First Posted: 2018-10-09
• Status Verified: 2022-11
• Last Update Submitted: 2022-11-17
• Last Update Posted: 2022-11-18
• Primary Completion: 2023-06-30
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 30000

Inclusion Criteria

health check subjects 30-90 years old low dose chest CT scan

Exclusion Criteria

pregnant women metal implant in the CT scan area

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The spinal volumetric bone mineral density (vBMD)	2 year	The volumetric bone mineral density of L1-2 measured by QCT

Secondary Outcome Measures

Name	Time	Method
Liver fat	2 years	Liver fat measurement by quantitative computed tomography (QCT)
The visceral adipose tissue (VAT)	2 year	The visceral adipose tissue (VAT) measured by quantitative computed tomography (QCT)

Trial Locations

Locations (6)

Beijing Jishuitan hospital; 🇨🇳 Beijing, Beijing, China

Wu Hu Yijishan Hospital; 🇨🇳 Wu Hu, Anhui, China

The first affiliated hospital of Guiyang Medical University; 🇨🇳 Guiyang, Guizhou, China

Shanghai Ruijin hospital; 🇨🇳 Shanghai, Shanghai, China

The first affiliated hospital of Zhengzhou University; 🇨🇳 Zhengzhou, Henan, China

Hua Shan hospital; 🇨🇳 Shanghai, Shanghai, China