A study comparing two different anti vomiting drugs in preventing injection pain of anesthesia inducing drug
- Conditions
- Laproscopic surgeries
- Registration Number
- CTRI/2018/01/011293
- Lead Sponsor
- Shamshuzoha M
- Brief Summary
Intravenous Propofol causes pain on injection, different drugs have been used to prevent Propofol injection pain 5HT3 receptor antagonist which are commonly used for prevention of nausea and vomiting are also used for having analgesic property. Different 5HT3 receptor antagonists were used as pretreatment in preventing this pain. In literature there are very minimal studies comparing Ondensetron and Palonosetron as pretreatment in preventing the Propofol injection pain.
The overall incidence of pain in group Ondensetron and group Palonosetron was 32% and 26% respectively. 4% of patient in group Ondensetron and 2% of patient in group Palonosetron complained of severe pain. Incidence of post operative nausea and vomiting in group Palonosetron (20%) was comparatively lower than group Ondensetron (38%).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 100
Posted for elective Laproscopic surgery under General anesthesia.
Patients with presence of infection on the dorsum of non-dominant hand Patients with thin dorsal veins Patients with known hypersensitivity to Propofol, Ondensetron and Palonosetron.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pain during injection of Propofol 1, 3 and 5 minute after induction
- Secondary Outcome Measures
Name Time Method Post operative nausea and vomiting Noted for 24 hours Post operative period
Trial Locations
- Locations (1)
Kempegowda Institute of Medical Sciences
🇮🇳Bangalore, KARNATAKA, India
Kempegowda Institute of Medical Sciences🇮🇳Bangalore, KARNATAKA, IndiaShamshuzoha MPrincipal investigator9742131215shamshuzoha@gmail.com