The Effect of Prebiotics on the Microbiome in Irritable Bowel Syndrome Patients: The Diet and Microbiome Study
- Conditions
- Irritable Bowel Syndrome
- Registration Number
- NCT01829932
- Lead Sponsor
- Queen's University
- Brief Summary
Irritable bowel syndrome (IBS) is a chronic gastrointestinal illness of unknown cause whose symptoms include abdominal pain, bloating and altered bowel pattern. Diet has been shown to influence the bacteria gut interaction. Our aim is to determine if components of the diet affect IBS symptoms by changing the bacteria gut interaction. In particular, we will measure whether after being on a diet high or low on certain factors there is a change in the timing and amount of hydrogen and methane produced by bacteria digesting lactulose and on IBS symptom severity.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 30
- Meet Rome III criteria for IBS
- Willing to undergo dietary intervention
- History of Gastric, Small Bowel or Colonic Surgery
- History of Inflammatory Bowel Disease
- Celiac Disease
- Unable to come off following medications: antibiotics, laxatives, narcotics, sedatives
- On a pre specified diet
- Pregnant
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Area under the Curve of Hydrogen Gas on Lactulose Breath Test 5 hours
- Secondary Outcome Measures
Name Time Method Change in Area Under the Curve on Lactulose Breath Test from Baseline 5 hours Change in IBS Symptom Severity Score from Baseline 3 weeks
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
Trial Locations
- Locations (1)
Hotel Dieu Hospital
🇨🇦Kingston, Ontario, Canada
Hotel Dieu Hospital🇨🇦Kingston, Ontario, Canada