The Association of Gut Microbiota With Urinary Tract Infection in Infants
试验速览
- 阶段
- 不适用
- 状态
- 撤回
- 发起方
- 试验地点
- 1
- 主要终点
- The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
研究概览
简要总结
This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.
详细描述
The investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 6 Months 至 15 Months（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Clinical diagnosis of febrile urinary tract infection.
排除标准
- •Congenital kidney disease
- •Congenital heart disease
- •Other metabolic disease
结局指标
主要结局
The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
时间窗: An average of 1 year, after the completion of recruitment.
The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2. From the OTU table, the investigators will conduct the differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection, using the linear discriminant analysis and analysis of differential abundance taking sample variation into account in R program and QIIME2.
次要结局
- The differential functional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.(An average of 1 year, after the completion of recruitment.)
研究者
Ky Young Cho
Associate Professor
Hallym University Kangnam Sacred Heart Hospital