The Association of Gut Microbiota With Urinary Tract Infection in Infants
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Urinary Tract Infections
- Sponsor
- Hallym University Kangnam Sacred Heart Hospital
- Locations
- 1
- Primary Endpoint
- The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
- Status
- Withdrawn
- Last Updated
- 4 years ago
Overview
Brief Summary
This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants.
Detailed Description
The investigators hypothesize that the gut environment reflected by intestinal microbiota influences the risk of urinary tract infection. This prospective case-control study will compare the gut microbiota between the infants with febrile urinary tract infection and healthy infants. The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2.
Investigators
Ky Young Cho
Associate Professor
Hallym University Kangnam Sacred Heart Hospital
Eligibility Criteria
Inclusion Criteria
- •Clinical diagnosis of febrile urinary tract infection.
Exclusion Criteria
- •Congenital kidney disease
- •Congenital heart disease
- •Other metabolic disease
Outcomes
Primary Outcomes
The differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.
Time Frame: An average of 1 year, after the completion of recruitment.
The investigators will sequence the V3-V4 of the bacterial 16SrRNA genes from the feces and analyze the sequencing data by QIIME2. From the OTU table, the investigators will conduct the differential compositional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection, using the linear discriminant analysis and analysis of differential abundance taking sample variation into account in R program and QIIME2.
Secondary Outcomes
- The differential functional analysis of the gut microbiota between healthy controls and infants with febrile urinary tract infection.(An average of 1 year, after the completion of recruitment.)