NCT03490916终止4 期
A Prospective, Double-blind, Randomized, Placebo-controlled Trial of Acetazolamide on Subclinical High-Altitude Pulmonary Edema Detected by Lung Ultrasonography
Vincent Kan1 个研究点 分布在 1 个国家目标入组 18 人开始时间: 2018年3月23日最近更新:
适应症
干预措施
试验速览
- 阶段
- 4 期
- 状态
- 终止
- 发起方
- 入组人数
- 18
- 试验地点
- 1
- 主要终点
- Pulmonary Edema Before and After Taking Acetazolamide
研究概览
简要总结
The overall goal of this study is to detect preclinical signs of HAPE by lung ultrasonography and evaluate the effectiveness of acetazolamide at decreasing pulmonary edema by using ultrasound.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •At least 18 years of age
- •Able to consent
- •English speaking
- •Trekking directly to Everest Base Camp
排除标准
- •Age less than 18 years
- •Non-English speaking
- •Already had a diagnosis of acute mountain sickness, high-altitude cerebral edema, or high-altitude pulmonary edema
- •Been on a high-altitude trek 2 weeks prior to this study
- •Has taken acetazolamide 1 week prior to start of trek
- •Has a sulfa allergy
- •Has any type of acute or chronic pulmonary conditions
研究组 & 干预措施
Acetazolamide normal dose
Experimental
One (1) dose of 250mg of Acetazolamide
干预措施: Acetazolamide (Drug)
Placebo
Placebo Comparator
One (1) dose of placebo
干预措施: Placebo (Drug)
结局指标
主要结局
Pulmonary Edema Before and After Taking Acetazolamide
时间窗: 1 month
Edema measured through ultrasound exam
次要结局
- Time to Completion of Ultrasound Exams(1 month)
研究者
Vincent Kan
Former Fellow, Department of Emergency Medicine
University of Massachusetts, Worcester
研究点 (1)
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