Consumption of Dairy Yogurt With Rhamnogalacturonan in Korean Citrus Hallabong Peel Polysaccharide Enhanced Immune Function and Attenuated Inflammatory Response
试验速览
- 阶段
- 2 期
- 状态
- 已完成
- 入组人数
- 120
- 试验地点
- 1
- 主要终点
- serum cytokine concentrations
研究概览
简要总结
To investigate the impact of consumption of dairy yogurt with rhamnogalacturonan (RG) in Korean citrus Hallabong peel polysaccharide on Natural Killer (NK) cell activity and circulating cytokine levels.
详细描述
A randomized, double-blind, placebo-controlled study was conducted on 120 nondiabetic and nonobese subjects. Over an 8 week period, the test group consumed one pack (150ml) of dairy yogurt with 50mg probiotics and 100mg Korean citrus Hallabong peel polysaccharide (60% RG, 20% mono- and di-saccharide, 5% polyphenol) each day, whereas the placebo group consumed the same product without Korean citrus Hallabong peel polysaccharide. NK cell activities (%) were measured based on the ratios of effector cells (E) (peripheral blood mononuclear cell, PBMC) from each participant to Target cell (T) (K562 cells) as 10:1, 5:1, 2.5:1 or 1.25:1.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Prevention
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 30 Years 至 69 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •The levels of white blood cells under 8x10^3/μL
- •males and females
- •30-69 years old
- •nondiabetic and nonobese subjects
- •able to give informed consent
排除标准
- •consumption of any probiotic products within 1 month before screening
- •unstable body weight (body-weight change > 2 kg within 3 months before screening)
- •history/presence of significant metabolic disease
- •pregnancy or breast-feeding
- •acute or chronic infection
- •liver disease, kidney disease, gastrointestinal disease, or any other acute or chronic disease requiring treatment
- •subjects taking any drugs or supplements
研究组 & 干预措施
test group
Dietary Supplement: RG consumed one pack (150ml) of dairy yogurt containing RG (100mg Korean citrus Hallabong peel polysaccharide) per day for 8 weeks
干预措施: RG (Dietary Supplement)
placebo
Dietary Supplement: placebo consumed one pack (150ml) of dairy yogurt without RG per day for 8 weeks
干预措施: Placebo (Dietary Supplement)
结局指标
主要结局
serum cytokine concentrations
时间窗: change from baseline in RG at 8 weeks
Primary outcome will be tested before and after intervention
次要结局
未报告次要终点