Inhaled Corticosteroids do Not Modify the Systemic Inflammation Induced by Exercise in Patients With Chronic Obstructive Pulmonary Disease
试验速览
- 阶段
- 4 期
- 状态
- 已完成
- 发起方
- 入组人数
- 23
- 试验地点
- 1
- 主要终点
- Differences in response to exercise between healthy and COPD patients
研究概览
简要总结
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
详细描述
Physical exercise produces a systemic inflammatory response, both in the healthy individual and in the COPD patient (Rabinovitch et al ERJ 2003; van Helvoort et al Respir Med 2005; Davidson WJ et al. J Appl Physiol). Nevertheless, although it has been described that some of the systemic biomarkers related with COPD (Protein C-Reactive (PCR), interleukin [IL]-8) are associated with a lower tolerance to exercise in COPD patients (García-Río et al. Respir Res 2010), the role of IC on systemic inflammation triggered by exercise in COPD patients remains unknown.
This study explores the hypothesis that the inflammatory response induced by exercise in COPD patients could be with IC treatment.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
入排标准
- 年龄范围
- 58 Years 至 72 Years（Adult, Older Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •ex-smokers (> 10 packets-year) with moderate-severe COPD patients
排除标准
- 未提供
研究组 & 干预措施
Inhaled Placebo
Inhaled placebo administered to healthy (n=7) and to a half (n=8) of COPD patients
干预措施: Inhaled Placebo (Drug)
Inhaled corticosteroids (Fluticasone, 0.5 mg)
Inhaled corticosteroids administered to the other half (n=8) of COPD patients
干预措施: Fluticasone (Drug)
结局指标
主要结局
Differences in response to exercise between healthy and COPD patients
时间窗: 1 month
16 COPD patients were compared with 7 healthy, sedentary and nonsmoker controls. All of them carried out an incremental cycle exercise test (ICET) limited by symptoms. 1 month later, ICET was repeated only by COPD patients. Venous blood samples were obtained at rest and during peak exercise. Anthropometric, functional and response characteristics to exercise: Age, years BMI, m2.kg-1 FEV1/FVC, % FEV1, % reference Peak charge, watts VO2 peak, mL.min-1 Respiratory quotient VE peak, L.min-1 Fc peak, lpm Lactic acid peak, mmol.L-1 SaO2 basal, % SaO2 peak, %
次要结局
未报告次要终点
研究者
Antonia Fuster
Medicine PhD
Hospital Son Llatzer