Inhaled Corticosteroids do Not Modify the Systemic Inflammation Induced by Exercise in Patients With Chronic Obstructive Pulmonary Disease
Overview
- Phase
- Phase 4
- Intervention
- Inhaled Placebo
- Conditions
- Chronic Obstructive Pulmonary Disease
- Sponsor
- Hospital Son Llatzer
- Enrollment
- 23
- Locations
- 1
- Primary Endpoint
- Differences in response to exercise between healthy and COPD patients
- Status
- Completed
- Last Updated
- 11 years ago
Overview
Brief Summary
Chronic obstructive pulmonary disease (COPD) is characterized by pulmonary and systemic inflammation. The effect of inhaled corticosteroids (IC) on inflammation in COPD is controversial.
Detailed Description
Physical exercise produces a systemic inflammatory response, both in the healthy individual and in the COPD patient (Rabinovitch et al ERJ 2003; van Helvoort et al Respir Med 2005; Davidson WJ et al. J Appl Physiol). Nevertheless, although it has been described that some of the systemic biomarkers related with COPD (Protein C-Reactive (PCR), interleukin \[IL\]-8) are associated with a lower tolerance to exercise in COPD patients (García-Río et al. Respir Res 2010), the role of IC on systemic inflammation triggered by exercise in COPD patients remains unknown. This study explores the hypothesis that the inflammatory response induced by exercise in COPD patients could be with IC treatment.
Investigators
Antonia Fuster
Medicine PhD
Hospital Son Llatzer
Eligibility Criteria
Inclusion Criteria
- •ex-smokers (\> 10 packets-year) with moderate-severe COPD patients
Exclusion Criteria
- Not provided
Arms & Interventions
Inhaled Placebo
Inhaled placebo administered to healthy (n=7) and to a half (n=8) of COPD patients
Intervention: Inhaled Placebo
Inhaled corticosteroids (Fluticasone, 0.5 mg)
Inhaled corticosteroids administered to the other half (n=8) of COPD patients
Intervention: Fluticasone
Outcomes
Primary Outcomes
Differences in response to exercise between healthy and COPD patients
Time Frame: 1 month
16 COPD patients were compared with 7 healthy, sedentary and nonsmoker controls. All of them carried out an incremental cycle exercise test (ICET) limited by symptoms. 1 month later, ICET was repeated only by COPD patients. Venous blood samples were obtained at rest and during peak exercise. Anthropometric, functional and response characteristics to exercise: Age, years BMI, m2.kg-1 FEV1/FVC, % FEV1, % reference Peak charge, watts VO2 peak, mL.min-1 Respiratory quotient VE peak, L.min-1 Fc peak, lpm Lactic acid peak, mmol.L-1 SaO2 basal, % SaO2 peak, %