Evaluation of the Effect of Acitretin Versus Narrowband Ultraviolet B on Serum Neopterin Level in Psoriatic Patients .
试验速览
- 阶段
- 4 期
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- Serum Neopterin in psoriasis
研究概览
简要总结
To evaluate effect of acitretin versus Narrowband UVB on serum level of neopterin in psoriatic patients.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 15 Years 至 60 Years（Child, Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with psoriasis diagnosed clinically Aged (15-60).
排除标准
- •Patient with history of skin cancer.
- •Patient with history of photosensitivity.
- •Pregnancy and lactation.
- •Liver failure.
- •Renal failure.
- •Patient with psoriatic artheritis.
- •Patient with allergy to product or any of its components.
- •Patient with poorly controlled dyslipidemia.
- •Patient receiving tetracyclines.
研究组 & 干预措施
Acitretin
Patients will Receive Acitretin (0.25-1 mg /kg/day )for 3months .
干预措施: Acitretin 25Mg Cap (Drug)
Narrowband ultraviolet B
Patients will receive Narrowband UVB( 3session /week ) for 3months.
干预措施: Narrowband ultraviolet B (Radiation)
Combination of Narrowband ultraviolet B and Acitretin
Patients will receive Acitretin (0.25-1 mg /kg/day ) and Narrowband UVB( 3session /week ) for 3 months.
干预措施: Acitretin 25Mg Cap (Drug)
Combination of Narrowband ultraviolet B and Acitretin
Patients will receive Acitretin (0.25-1 mg /kg/day ) and Narrowband UVB( 3session /week ) for 3 months.
干预措施: Narrowband ultraviolet B (Radiation)
结局指标
主要结局
Serum Neopterin in psoriasis
时间窗: 3 Months
Measurement of Neopterin in psoriatic patients before and after treatment with NB-UVB, Acitretin and combination of both modalities using ELISA (enzyme-linked immunosorbent assay).
次要结局
- Treatment of psoriasis(3 Months)
研究者
Fatma Elsayed abd Elfatah Elsayed
Resident doctor
South Valley University