Endoscopic Size Assessment of Advanced Adenomatous Polyps

Completed

• Conditions: Adenoma Detection Rate Improvement in Screening Colonoscopy

• Registration Number: NCT02193646
• Lead Sponsor: Rush University Medical Center

Brief Summary

The investigators are retrospectively comparing detection rates of adenomatous polyps, advanced adenomas, and size assessment of the polyps among Rush University Medical Center endoscopists. The investigators plan to review whether the size assessment of adenomatous polyps affected the surveillance protocols and if the location of polyps detected affected the detection rates.

Detailed Description

The study plans to compare detection rates of adenomatous as well as the sessile serrated polyps, advanced adenomas and size assessment of the polyps among the endoscopists at the study site. In addition, the study team aims to evaluate rates of advanced neoplasia on surveillance colonoscopy based on certain features on initial colonoscopy and patient characteristics, including specific high-risk histologic features and concurrent medication usage such as aspirin. In addition, patients with at least one adenoma on surveillance colonoscopy will be identified and regarded as cases. Cases will be compared against normal surveillance colonoscopy. The Controls will be selected on a 1:1 ratio. Aspirin use will be compared between groups.

Study Timeline

• Study Start: 2010-11
• Study First Submitted: 2014-07-14
• Study First Submitted QC: 2014-07-15
• Study First Posted: 2014-07-17
• Status Verified: 2025-01
• Primary Completion: 2025-01
• Study Completion: 2025-01
• Last Update Submitted: 2025-01-17
• Last Update Posted: 2025-03-25

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 1930

Inclusion Criteria

• Presence of adenomatous polyps detected at endoscopy and diagnosed pathologically by tissue biopsy
• Have a colonoscopy at RUMC for screening purposes

Exclusion Criteria

• Failure to meet inclusion criteria
• Previous diagnosis of IBD or colorectal cancer

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Endoscopic Size Assessment Versus Pathological Size Assessment	one year	Size of polyps at time of endoscopic procedure will be compared to the size of the same polyp by pathological assessment.
Adenomatous Polyp Detection Rate	one year	Assessing for advanced adenomas (including location).

Secondary Outcome Measures

Name	Time	Method
Retroflexion as an indication of adenoma detection rate in colorectal cancer screening	one year	Retroflexion is a common but not mandatory practice in colonoscopy which as not been systematically studied in terms of polyp detection. Charts will be reviewed to determine whether retroflexion was performed.

Trial Locations

Locations (1)

Amanda Lin; 🇺🇸 Chicago, Illinois, United States